Publications

Member Publications

Members of the NASH Roundtable™ contribute important research to the public domain through peer-reviewed articles in medical journals. Below is a selection of recent research co-authored by Roundtable members. For a comprehensive search of NASH-related research by Roundtable members and others, visit pubmed.gov.

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September, 2022

The Cost of Diagnosing and Managing Non-alcoholic Steatohepatitis in Europe and the United States

Geier A, Heinz S, Balp MM, Brass C, Pedrosa M, Cai J, Hoad R, Sayadian AC, Rinella M, Ratziu V. J Gastrointestin Liver Dis. 2022 Sep 15;31(3):317-322. doi: 10.15403/jgld-4275.

Member Publications

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The Cost of Diagnosing and Managing Non-alcoholic Steatohepatitis in Europe and the United States

Clinical Utility of Combined MRI-PDFF and ALT Response in Predicting Histologic Response in Nonalcoholic Fatty Liver Disease

Geographical similarity and differences in the burden and genetic predisposition of NAFLD

Non-alcoholic steatohepatitis

Interactive Role of Surrogate Liver Fibrosis Assessment and Insulin Resistance on the Incidence of Major Cardiovascular Events

Analysis of a Simulation Model to Estimate Long-term Outcomes in Patients with Nonalcoholic Fatty Liver Disease

Diagnostic scores and scales for appraising Nonalcoholic fatty liver disease and omics perspectives for precision medicine

Review article: the epidemiologic burden of non-alcoholic fatty liver disease across the world

Global burden of liver cancer in males and females: Changing etiological basis and the growing contribution of NASH

Shared mechanisms between cardiovascular disease and NAFLD

Management of NAFLD in primary care settings

Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease

Metabolic factors predict changes in endothelial function during the early course of type 1 and type 2 diabetes

Head-to-head comparison between MEFIB, MAST, and FAST for detecting stage 2 fibrosis or higher among patients with NAFLD

Historical Changes in Weight Classes and the Influence of NAFLD Prevalence: A Population Analysis of 34,486 Individuals

Developing and pilot testing an oral health screening tool for diabetes care providers

Hypertension is prevalent in non-alcoholic fatty liver disease and increases all-cause and cardiovascular mortality

Living in the non-alcoholic fatty liver disease silent epidemic: a qualitative systematic review of patients’ perspectives

The prevalence of alcoholic and nonalcoholic fatty liver disease in adolescents and young adults in the United States: analysis of the NHANES database

Adipose tissue dysfunction and visceral fat are associated with hepatic insulin resistance and severity of NASH even in lean individuals

Treatments for obesity in the context of nonalcoholic steatohepatitis and mental health

Behavioral health disorders related to nonalcoholic steatohepatitis

Elevated de novo lipogenesis, slow liver triglyceride turnover, and clinical correlations in nonalcoholic steatohepatitis patients

Nonalcoholic steatohepatitis medical patient journey from the perspective of hepatologists, gastroenterologists and patients: a cross-sectional survey

The Prevalence and Determinants of NAFLD and MAFLD and Their Severity in the VA Primary Care Setting

Liver stiffness accuracy by MR elastography in histologically proven non-alcoholic fatty liver disease patients: a Spanish cohort

Age and the relative importance of liver-related deaths in nonalcoholic fatty liver disease

Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer

The scaffold-dependent function of RIPK1 in experimental non-alcoholic steatohepatitis

Liver Stiffness on Magnetic Resonance Elastography and the MEFIB Index and Liver-Related Outcomes in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Individual Participants

Fatty liver indices and their association with glucose metabolism in pregnancy – An observational cohort study.

A Randomized, Single Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Novel Insulin Dimer

Digital pathology with artificial intelligence analyses provides greater insights into treatment-induced fibrosis regression in NASH

Current therapies and new developments in NASH

Noninvasive Diagnosis of Nonalcoholic Steatohepatitis and Advanced Liver Fibrosis Using Machine Learning Methods: Comparative Study With Existing Quantitative Risk Scores

Breakthroughs in therapies for NASH and remaining challenges

A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation

Clinical features and outcomes of NAFLD-related hepatocellular carcinoma – Authors’ reply

African genetic ancestry is associated with lower frequency of PNPLA3 G allele in non-alcoholic fatty liver in an admixed population

Incidence of Type 2 Diabetes in Children With Nonalcoholic Fatty Liver Disease

Artificial Intelligence Improves Pathologist Agreement for Fibrosis Scores in Nonalcoholic Steatohepatitis Patients

Hepatic Stellate Cell-Immune Interactions in NASH

Comorbidities in Recent-Onset Adult Type 1 Diabetes: A Comparison of German Cohorts

Bone morphogenetic protein 2 is a new molecular target linked to non-alcoholic fatty liver disease with potential value as non-invasive screening tool

The Effect of Diabetes and Prediabetes on the Prevalence, Complications and Mortality in Non-alcoholic Fatty Liver Disease

Prevalence estimation of significant fibrosis due to NASH in Spain combining transient elastography and histology

Changes in the gut microbiome associated with liver stiffness improvement in nonalcoholic steatohepatitis

Clinicians’ Perspectives on Barriers and Facilitators for the Adoption of Non-Invasive Liver Tests for NAFLD: A Mixed-Method Study

Metabolic reprogramming of the intestinal microbiome with functional bile acid changes underlie the development of NAFLD

Nonalcoholic fatty liver disease prevalence and severity in Asian Americans from the national health and nutrition examination surveys 2017-2018

Comprehensive Review and Updates on Holistic Approach Towards Non-Alcoholic Fatty Liver Disease Management with Cardiovascular Disease

Emerging advances in the pharmacologic treatment of nonalcoholic steatohepatitis and related cirrhosis

American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings: Co-Sponsored by the American Association for the Study of Liver Diseases (AASLD)

NAFLD/NASH

American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings: Co-Sponsored by the American Association for the Study of Liver Diseases (AASLD)

Mortality Outcomes by Fibrosis Stage in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis

Response to: “Nonalcoholic fatty liver disease in diabetes: Overlooked or just ignored?”

Adipose tissue measurement in clinical research for obesity, type 2 diabetes and NAFLD/NASH

A global view of the interplay between non-alcoholic fatty liver disease and diabetes.

Impaired Hepatic Mitochondrial Capacity in Nonalcoholic Steatohepatitis Associated With Type 2 Diabetes.

Comparative efficacy of an optimal exam between ultrasound versus abbreviated MRI for HCC screening in NAFLD cirrhosis: A prospective study.

A nutrigenetic tool for precision dietary management of NAFLD deeming insulin resistance markers

Redefinition of Fatty Liver Disease from NAFLD to MAFLD through the Lens of Drug Development and Regulatory Science

Greater ectopic fat deposition and liver fibroinflammation, and lower skeletal muscle mass in people with type 2 diabetes

Risk of liver-related events by age and diabetes duration in diabetic patients with non-alcoholic fatty liver disease.

Direct Comparison of Quantitative US versus Controlled Attenuation Parameter for Liver Fat Assessment Using MRI Proton Density Fat Fraction as the Reference Standard in Patients Suspected of Having NAFLD.

Noninvasive assessment of liver fibrosis and its clinical significance in nonalcoholic fatty liver disease.

Non-Alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet.

A Simple Test to Identify the Risk of NASH and Cirrhosis in People with Obesity or Diabetes: The Time to Screen is Now.

Reliability of Histologic Assessment for NAFLD and Development of an Expanded NAFLD Activity Score.

Aldafermin in patients with non-alcoholic steatohepatitis (ALPINE 2/3): a randomised, double-blind, placebo-controlled, phase 2b trial.

Is lean non-alcoholic fatty liver disease a distinct entity?

Systematic review and meta-analysis: analysis of variables influencing the interpretation of clinical trial results in NAFLD.

Meta-analysis: analysis of mechanistic pathways in the treatment of non-alcoholic steatohepatitis. Evidence from a Bayesian network meta-analysis.

Clinical Interest of Serum Alpha-2 Macroglobulin, Apolipoprotein A1, and Haptoglobin in Patients with Non-Alcoholic Fatty Liver Disease, with and without Type 2 Diabetes, before or during COVID-19.

Comparison of clinical prediction rules for ruling out cirrhosis in nonalcoholic fatty liver disease (NAFLD).

Clinical characteristics, surveillance, treatment allocation, and outcomes of non-alcoholic fatty liver disease-related hepatocellular carcinoma: a systematic review and meta-analysis.

Variation in Alanine Aminotransferase in Children with Non-Alcoholic Fatty Liver Disease.

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis.