Publications

Members of the Metabolic Continuum Roundtable™ contribute important research to the public domain through peer-reviewed articles in medical journals. Below is a selection of recent research co-authored by Roundtable contributors. For a comprehensive search of metabolic-related research by Roundtable contributors and others, visit pubmed.gov.

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Safety and efficacy of once-daily HU6 versus placebo in people with non-alcoholic fatty liver disease and high BMI: a randomised, double-blind, placebo-controlled, phase 2a trial.

Noureddin M, Khan S, Portell F, Jorkasky D, Dennis J, Khan O, Johansson L, Johansson E, Sanyal AJ. Lancet Gastroenterol Hepatol. 2023 Dec;8(12):1094-1105. doi: 10.1016/S2468-1253(23)00198-X.

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Nutrition assessment and MASH severity in children using the Healthy Eating Index.

Jain AK, Buchannan P, Yates KP, Belt P, Schwimmer JB, Rosenthal P, Murray KF, Molleston JP, Scheimann A, Xanthakos SA, Behling CA, Hertel P, Nilson J, Neuschwander-Tetri BA, Tonascia J, Vos MB; Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN). Hepatol Commun. 2023 Dec 7;7(12):e0320. doi: 10.1097/HC9.0000000000000320.

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Impact of Type 2 Diabetes on the Outcomes of Solid Organ Transplantations in the U.S.: Data From a National Registry.

Stepanova M, Kumar A, Brandt P, Gundurao N, Cusi K, Al Qahtani S, Younossi ZM. Diabetes Care. 2023 Dec 1;46(12):2162-2170. doi: 10.2337/dc23-1085.

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Bifidobacteria metabolize lactulose to optimize gut metabolites and prevent systemic infection in patients with liver disease.

Odenwald MA, Lin H, Lehmann C, Dylla NP, Cole CG, Mostad JD, Pappas TE, Ramaswamy R, Moran A, Hutchison AL, Stutz MR, Dela Cruz M, Adler E, Boissiere J, Khalid M, Cantoral J, Haro F, Oliveira RA, Waligurski E, Cotter TG, Light SH, Beavis KG, Sundararajan A, Sidebottom AM, Reddy KG, Paul S, Pillai A, Te HS, Rinella ME, Charlton MR, Pamer EG, Aronsohn AI. Nat Microbiol. 2023 Nov;8(11):2033-2049. doi: 10.1038/s41564-023-01493-w.

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The Impact and Burden of Dietary Sugars on the Liver.

Huneault HE, Ramirez Tovar A, Sanchez-Torres C, Welsh JA, Vos MB. Hepatol Commun. 2023 Nov 6;7(11):e0297. doi: 10.1097/HC9.0000000000000297.

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A randomised Phase IIa trial of amine oxidase copper-containing 3 (AOC3) inhibitor BI 1467335 in adults with non-alcoholic steatohepatitis.

Newsome PN, Sanyal AJ, Neff G, Schattenberg JM, Ratziu V, Ertle J, Link J, Mackie A, Schoelch C, Lawitz E; BI 1467335 NASH Phase IIa trial team. Nat Commun. 2023 Nov 6;14(1):7151. doi: 10.1038/s41467-023-42398-w.

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Diabetes mellitus, energy metabolism and COVID-19.

Conte C, Cipponeri E, Roden M. Endocr Rev. 2023 Nov 2:bnad032. doi: 10.1210/endrev/bnad032. Online ahead of print.PMID: 37934800

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A nutrigenetic precision approach for the management of non-alcoholic fatty liver disease.

Perez-Diaz-Del-Campo N, Dileo E, Castelnuovo G, Nicolosi A, Guariglia M, Caviglia GP, Rosso C, Armandi A, Bugianesi E. Clin Nutr. 2023 Nov;42(11):2181-2187. doi: 10.1016/j.clnu.2023.09.022.

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Mechanisms of weight loss-induced remission in people with prediabetes: a post-hoc analysis of the randomised, controlled, multicentre Prediabetes Lifestyle Intervention Study (PLIS).

Sandforth A, von Schwartzenberg RJ, Arreola EV, Hanson RL, Sancar G, Katzenstein S, Lange K, Preißl H, Dreher SI, Weigert C, Wagner R, Kantartzis K, Machann J, Schick F, Lehmann R, Peter A, Katsouli N, Ntziachristos V, Dannecker C, Fritsche L, Perakakis N, Heni M, Nawroth PP, Kopf S, Pfeiffer AFH, Kabisch S, Stumvoll M, Schwarz PEH, Hauner H, Lechner A, Seissler J, Yurchenko I, Icks A, Solimena M, Häring HU, Szendroedi J, Schürmann A, de Angelis MH, Blüher M, Roden M, Bornstein SR, Stefan N, Fritsche A, Birkenfeld AL. Lancet Diabetes Endocrinol. 2023 Nov;11(11):798-810. doi: 10.1016/S2213-8587(23)00235-8.

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Looking for the best algorithm in diabetes population for advanced fibrosis detection: The best is the enemy of the good.

Stepanova M, Kumar A, Brandt P, Gundurao N, Cusi K, Al Qahtani S, Younossi ZM. Diabetes Care. 2023 Dec 1;46(12):2162-2170. doi: 10.2337/dc23-1085.

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Diagnosis and assessment of disease severity in patients with nonalcoholic fatty liver disease.

Li J, Delamarre A, Wong VW, de Lédinghen V. United European Gastroenterol J. 2023 Nov 21. doi: 10.1002/ueg2.12491.

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Low liver fat in non-alcoholic steatohepatitis-related significant fibrosis and cirrhosis is associated with hepatocellular carcinoma, decompensation and mortality.

Lee SW, Huang DQ, Bettencourt R, Ajmera V, Tincopa M, Noureddin N, Amangurbanova M, Siddiqi H, Madamba E, Majzoub AM, Nayfeh T, Tamaki N, Izumi N, Nakajima A, Yoneda M, Idilman R, Gumussoy M, Oz DK, Erden A, Loomba R. Aliment Pharmacol Ther. 2023 Nov 15. doi: 10.1111/apt.17783.

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Global survey of stigma among physicians and patients with nonalcoholic fatty liver disease.

Younossi ZM, AlQahtani SA, Alswat K, Yilmaz Y, Keklikkiran C, Funuyet-Salas J, Romero-Gómez M, Fan JG, Zheng MH, El-Kassas M, Castera L, Liu CJ, Wai-Sun Wong V, Zelber-Sagi S, Allen AM, Lam B, Treeprasertsuk S, Hameed S, Takahashi H, Kawaguchi T, Schattenberg JM, Duseja A, Newsome P, Francque S, Spearman CW, Castellanos Fernández MI, Burra P, Roberts SK, Chan WK, Arrese M, Silva M, Rinella M, Singal AK, Gordon S, Fuchs M, Alkhouri N, Cusi K, Loomba R, Ranagan J, Eskridge W, Kautz A, Ong JP, Kugelmas M, Eguchi Y, Diago M, Yu ML, Gerber L, Fornaresio L, Nader F, Henry L, Racila A, Golabi P, Stepanova M, Carrieri P, Lazarus JV; Global NASH Council. J Hepatol. 2023 Nov 18:S0168-8278(23)05279-0. doi: 10.1016/j.jhep.2023.11.004.

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Risk factors for fibrosis progression in non-alcoholic steatohepatitis: analysis of the European cohort in the real-world GAIN study.

Shaikh A, Pedra G, Ruiz-Casas L, Franks B, Dhillon H, Fernandes JDDR, Mangla KK, Augusto M, Romero-Gómez M, Schattenberg JM. Gastroenterol Hepatol. 2023 Oct 25:S0210-5705(23)00451-X. doi: 10.1016/j.gastrohep.2023.10.005.

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Homeostasis Model Assessment of β-Cell Function for Diagnosis of Insulinoma.

Bódis K, Schön M, Dauben L, Wilker M, Strassburger K, Burkart V, Roden M, Müssig K. J Clin Endocrinol Metab. 2023 Oct 27:dgad618. doi: 10.1210/clinem/dgad618.

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Development and validation of an image biomarker to identify metabolic dysfunction associated steatohepatitis: MR-MASH score.

Marti-Aguado D, Arnouk J, Liang JX, Lara-Romero C, Behari J, Furlan A, Jimenez-Pastor A, Ten-Esteve A, Alfaro-Cervello C, Bauza M, Gallen-Peris A, Gimeno-Torres M, Merino-Murgui V, Perez-Girbes A, Benlloch S, Pérez-Rojas J, Puglia V, Ferrández-Izquierdo A, Aguilera V, Giesteira B, França M, Monton C, Escudero-García D, Alberich-Bayarri Á, Serra MA, Bataller R, Romero-Gomez M, Marti-Bonmati L. Liver Int. 2023 Oct 30. doi: 10.1111/liv.15766.

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Impact of physical fitness and exercise training on subcutaneous adipose tissue beiging markers in humans with and without diabetes and a high-fat diet-fed mouse model.

Bódis K, Breuer S, Crepzia-Pevzner A, Zaharia OP, Schön M, Saatmann N, Altenhofen D, Springer C, Szendroedi J, Wagner R, Al-Hasani H, Roden M, Pesta D, Chadt A; GDS Group. Diabetes Obes Metab. 2023 Oct 23. doi: 10.1111/dom.15322.

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Precise glucose measurement in sodium fluoride-citrate plasma affects estimates of prevalence in diabetes and prediabetes.

Heilmann G, Trenkamp S, Möser C, Bombrich M, Schön M, Yurchenko I, Strassburger K, Rodríguez MM, Zaharia OP, Burkart V, Wagner R, Roden M. Clin Chem Lab Med. 2023 Oct 24. doi: 10.1515/cclm-2023-0770.

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Reduced Insulin Clearance Differently Relates to Increased Liver Lipid Content and Worse Glycemic Control in Recent-Onset Type 2 and Type 1 Diabetes.

Zaharia OP, Antoniou S, Bobrov P, Karusheva Y, Bódis K, Kupriyanova Y, Schrauwen-Hinderling V, Gastaldelli A, Szendroedi J, Wagner R, Burkart V, Roden M; GDS Group. Diabetes Care. 2023 Oct 24:dc231267. doi: 10.2337/dc23-1267.

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A prospective, multicenter, three-cohort study evaluating contrast-induced acute kidney injury (CI-AKI) in patients with cirrhosis.

Campion D, Ponzo P, Risso A, Caropreso P, Caviglia GP, Sanavia T, Frigo F, Bonetto S, Giovo I, Rizzo M, Martini S, Bugianesi E, Mengozzi G, Marzano A, Manca A, Saracco GM, Alessandria C. J Hepatol. 2023 Oct 20:S0168-8278(23)05176-0. doi: 10.1016/j.jhep.2023.10.010.

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Digital pathology and artificial intelligence in non-alcoholic steatohepatitis: current status and future directions.

Ratziu V, Hompesch M, Petitjean M, Serdjebi C, Iyer JS, Parwani AV, Tai D, Bugianesi E, Cusi K, Friedman SL, Lawitz E, Romero-Gómez M, Schuppan D, Loomba R, Paradis V, Behling C, Sanyal AJ. J Hepatol. 2023 Oct 23:S0168-8278(23)05182-6. doi: 10.1016/j.jhep.2023.10.015.

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Validation of AGA clinical care pathway and AASLD practice guidance for nonalcoholic fatty liver disease in a prospective cohort of patients with type 2 diabetes.

Ajmera V, Tesfai K, Sandoval E, Lopez S, Cervantes V, Madamba E, Bettencourt R, Manousou P, Richards L, Loomba R. Hepatology. 2023 Oct 20. doi: 10.1097/HEP.0000000000000635.

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Long-term follow-up of web-based and group-based behavioural intervention in NAFLD in a real world clinical setting.

Petroni ML, Colosimo S, Brodosi L, Armandi A, Bertini F, Montesi D, Bugianesi E, Marchesini G. Aliment Pharmacol Ther. 2023 Oct 16. doi: 10.1111/apt.17768.

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Inter-organ crosstalk during development and progression of type 2 diabetes mellitus.

Xourafa G, Korbmacher M, Roden M. Nat Rev Endocrinol. 2023 Oct 16. doi: 10.1038/s41574-023-00898-1.

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Nutrition could prevent or promote non-alcoholic fatty liver disease: an opportunity for intervention.

Romero-Gómez M, Zelber-Sagi S, Martín F, Bugianesi E, Soria B. BMJ. 2023 Oct 9;383:e075179. doi: 10.1136/bmj-2023-075179.

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Correlates of Skeletal Muscle Mass and Differences Between Novel Subtypes in Recent-onset Diabetes.

Herder C, Maalmi H, Saatmann N, Zaharia OP, Strassburger K, Burkart V, Norman K, Roden M. J Clin Endocrinol Metab. 2023 Oct 13:dgad605. doi: 10.1210/clinem/dgad605.

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Risk of severe infection in patients with non-alcoholic fatty liver disease: Implication on clinical management.

Wang MY, Wong VW, Yip TC. Liver Int. 2023 Oct;43(10):2057-2059. doi: 10.1111/liv.15696.

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Artificial intelligence-assisted digital pathology for non-alcoholic steatohepatitis: current status and future directions.

Ratziu V, Hompesch M, Petitjean M, Serdjebi C, Iyer JS, Parwani AV, Tai D, Bugianesi E, Cusi K, Friedman SL, Lawitz E, Romero-Gómez M, Schuppan D, Loomba R, Paradis V, Behling C, Sanyal AJ. Hepatology. 2023 Oct 24. doi:10.1016/j.jhep.2023.10.015.

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Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women.

Cherubini A, Ostadreza M, Jamialahmadi O, Pelusi S, Rrapaj E, Casirati E, Passignani G, Norouziesfahani M, Sinopoli E, Baselli G, Meda C, Dongiovanni P, Dondossola D, Youngson N, Tourna A, Chokshi S, Bugianesi E; EPIDEMIC Study Investigators; Della Torre S, Prati D, Romeo S, Valenti L. Nat Med. 2023 Sep 25. doi: 10.1038/s41591-023-02553-8.

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A randomized, double-blind, placebo-controlled trial of Aldafermin in patients with nonalcoholic steatohepatitis and compensated cirrhosis.

Rinella ME, Lieu HD, Kowdley KV, Goodman ZD, Alkhouri N, Lawitz E, Ratziu V, Abdelmalek MF, Wong VW, Younes ZH, Sheikh AM, Brannan D, Freilich B, Membreno F, Sinclair M, Melchor-Khan L, Sanyal AJ, Ling L, Harrison SA. Hepatology. 2023 Sep 21. doi: 10.1097/HEP.0000000000000607.

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Impact of Type 2 Diabetes on the Outcomes of Solid Organ Transplantations in the U.S.: Data From a National Registry.

Stepanova M, Kumar A, Brandt P, Gundurao N, Cusi K, Al Qahtani S, Younossi ZM. Diabetes Care. 2023 Sep 25:dc231085. doi: 10.2337/dc23-1085.

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MAFLD fibrosis score: Using routine measures to identify advanced fibrosis in metabolic-associated fatty liver disease.

Cheung JTK, Zhang X, Wong GL, Yip TC, Lin H, Li G, Leung HH, Lai JC, Mahadeva S, Nik Mustapha NR, Wang XD, Liu WY, Wong VW, Chan WK, Zheng MH. Aliment Pharmacol Ther. 2023 Sep 19. doi: 10.1111/apt.17722.

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Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase.

Hummel J, Benkendorff C, Fritsche L, Prystupa K, Vosseler A, Gancheva S, Trenkamp S, Birkenfeld AL, Preissl H, Roden M, Häring HU, Fritsche A, Peter A, Wagner R, Kullmann S, Heni M. Nat Metab. 2023 Sep;5(9):1475-1482. doi: 10.1038/s42255-023-00869-w.

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Global Epidemiology of Cirrhosis: Changing Etiological Basis and Comparable Burden of NASH between Males and Females.

Tan D, Chan KE, Wong ZY, Ng CH, Xiao J, Lim WH, Tay P, Tang A, Fu CE, Muthiah M, Nah B, Tan EX, Teng MLP, Siddiqui MS, Dan YY, Lim SG, Loomba R, Huang DQ. Dig Dis. 2023 Sep 13. doi: 10.1159/000533946.

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Pegozafermin for NASH – A Sprint to Start a Marathon.

Rinella ME. N Engl J Med. 2023 Sep 14;389(11):1044-1046. doi: 10.1056/NEJMe2307249.

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Association of thyroid function with non-alcoholic fatty liver disease in recent-onset diabetes.

Saatmann N, Schön M, Zaharia OP, Huttasch M, Strassburger K, Trenkamp S, Kupriyanova Y, Schrauwen-Hinderling V, Kahl S, Burkart V, Wagner R, Roden M; GDS Group. Liver Int. 2023 Sep 12. doi: 10.1111/liv.15723.

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Clinical trial: Effects of pegozafermin on the liver and on metabolic comorbidities in subjects with biopsy-confirmed nonalcoholic steatohepatitis.

Alkhouri N, Lazas D, Loomba R, Frias JP, Feng S, Tseng L, Balic K, Agollah GD, Kwan T, Iyer JS, Morrow L, Mansbach H, Margalit M, Harrison SA. Aliment Pharmacol Ther. 2023 Sep 18. doi: 10.1111/apt.17709.

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Accuracy, reliability and comprehensiveness of ChatGPT generated medical responses for patients with NAFLD.

Pugliese N, Wong VW, Schattenberg JM, Romero-Gomez M, Sebastiani G; NAFLD Expert Chatbot Working Group; Aghemo A. Clin Gastroenterol Hepatol. 2023 Sep 14:S1542-3565(23)00704-8. doi: 10.1016/j.cgh.2023.08.033.

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NAFLD: Diagnostics and New Nomenclature.

Kanagalingam G, Sanyal AJ. J Clin Exp Hepatol. 2023 Sep-Oct;13(5):723-724. doi: 10.1016/j.jceh.2023.07.003.

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Utilization of Food-Derived β-Glucans to Prevent and Treat Non-Alcoholic Fatty Liver Disease (NAFLD).

Kei N, Wong VWS, Lauw S, You L, Cheung PCK. Foods. 2023 Sep 1;12(17):3279. doi: 10.3390/foods12173279.

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Pioneering the path to NASH biomarker approval.

Krag A, Rinella ME. Nat Med. 2023 Sep 7. doi: 10.1038/s41591-023-02527-w.

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Diagnostic performance of circulating biomarkers for non-alcoholic steatohepatitis.

Sanyal AJ, Shankar SS, Yates KP, Bolognese J, Daly E, Dehn CA, Neuschwander-Tetri B, Kowdley K, Vuppalanchi R, Behling C, Tonascia J, Samir A, Sirlin C, Sherlock SP, Fowler K, Heymann H, Kamphaus TN, Loomba R, Calle RA. Nat Med. 2023 Sep 7. doi: 10.1038/s41591-023-02539-6.

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The silent burden of non-alcoholic fatty liver disease in the elderly: A global burden of disease analysis.

Danpanichkul P, Ng CH, Muthiah MD, Duangsonk K, Yong JN, Tan DJH, Lim WH, Wong ZY, Syn N, Tsusumi T, Takahashi H, Siddiqui MS, Wong VW, Mantzoros CS, Huang DQ, Noureddin M, Loomba R, Sanyal AJ, Wijarnpreecha K. Aliment Pharmacol Ther. 2023 Sep 11. doi: 10.1111/apt.17714.

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Effects of TM6SF2 rs58542926 polymorphism on hepatocellular lipids and insulin resistance in early type 2 diabetes.

Bódis K, Bombrich M, Schön M, Knebel B, Zaharia OP, Bönhof G, Karusheva Y, Strassburger K, Kupriyanova Y, Kotzka J, Guthoff R, Schrauwen-Hinderling V, Al-Hasani H, Burkart V, Szendroedi J, Wagner R, Markgraf DF, Roden M; GDS study group. Nutr Metab Cardiovasc Dis. 2023 Sep;33(9):1785-1796. doi: 10.1016/j.numecd.2023.06.004.

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NIS2+™, an optimisation of the blood-based biomarker NIS4® technology for the detection of at-risk NASH: A prospective derivation and validation study.

Harrison SA, Ratziu V, Magnanensi J, Hajji Y, Deledicque S, Majd Z, Rosenquist C, Hum DW, Staels B, Anstee QM, Sanyal AJ. J Hepatol. 2023 Sep;79(3):758-767. doi: 10.1016/j.jhep.2023.04.031.

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Nonalcoholic fatty liver disease (NAFLD) and associated mortality in individuals with type 2 diabetes, pre-diabetes, metabolically unhealthy, and metabolically healthy individuals in the United States.

Golabi P, Paik JM, Kumar A, Al Shabeeb R, Eberly KE, Cusi K, GunduRao N, Younossi ZM. Metabolism. 2023 Sep;146:155642. doi: 10.1016/j.metabol.2023.155642.

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Oesophageal varices predict complications in compensated advanced non-alcoholic fatty liver disease.

Pennisi G, Enea M, Viganò M, Schepis F, de Ledinghen V, Berzigotti A, Wai-Sun Wong V, Fracanzani AL, Sebastiani G, Lara-Romero C, Bugianesi E, Svegliati-Baroni G, Marra F, Aghemo A, Valenti L, Calvaruso V, Colecchia A, Di Maria G, La Mantia C, Lin H, Mendoza YP, Pugliese N, Ravaioli F, Romero-Gomez M, Saltini D, Craxì A, Di Marco V, Cammà C, Petta S. JHEP Rep. 2023 Jun 7;5(9):100809. doi: 10.1016/j.jhepr.2023.100809.

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Progression of nonalcoholic fatty liver disease and long-term outcomes: A nationwide paired liver biopsy cohort study.

Simon TG, Roelstraete B, Hagström H, Loomba R, Ludvigsson JF. J Hepatol. 2023 Aug 19:S0168-8278(23)05063-8. doi: 10.1016/j.jhep.2023.08.008.

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Development, validation, and prognostic evaluation of a risk score for long-term liver-related outcomes in the general population: a multicohort study.

Serra-Burriel M, Juanola A, Serra-Burriel F, Thiele M, Graupera I, Pose E, Pera G, Grgurevic I, Caballeria L, Piano S, van Kleef L, Reichert M, Roulot D, Pericàs JM, Schattenberg JM, Tsochatztis EA, Guha IN, Garcia-Retortillo M, Hernández R, Hoyo J, Fuentes M, Expósito C, Martínez A, Such P, Madir A, Detlefsen S, Tonon M, Martini A, Ma AT, Pich J, Bonfill E, Juan M, Soria A, Carol M, Gratacós-Ginès J, Morillas RM, Toran P, Navarrete JM, Torrejón A, Fournier C, Llorca A, Arslanow A, de Koning HJ, Cucchietti F, Manns M, Newsome PN, Hernáez R, Allen A, Angeli P, de Knegt RJ, Karlsen TH, Galle P, Wong VW, Fabrellas N, Castera L, Krag A, Lammert F, Kamath PS, Ginès P; LiverScreen Consortium Investigators. Lancet. 2023 Aug 9:S0140-6736(23)01174-1. doi: 10.1016/S0140-6736(23)01174-1.

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Semaglutide in NASH-related cirrhosis: still a long way to go? – Authors’ reply.

Loomba R, Newsome PN. Lancet Gastroenterol Hepatol. 2023 Aug;8(8):694-695. doi: 10.1016/S2468-1253(23)00160-7.

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Clinical care pathway to detect advanced liver disease in patients with type 2 diabetes through automated fibrosis score calculation and electronic reminder messages: a randomised controlled trial.

Zhang X, Yip TC, Wong GL, Leow WX, Liang LY, Lim LL, Li G, Ibrahim L, Lin H, Lai JCT, Chim AM, Chan HLY, Kong AP, Chan WK, Wong VW. Gut. 2023 Aug 7:gutjnl-2023-330269. doi: 10.1136/gutjnl-2023-330269.

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Advanced liver fibrosis predicts heart failure and hospitalizations in people with type 2 diabetes: A prospective cohort study from Hong Kong Diabetes Register.

Kong AP, Lau ES, O CK, Luk AO, Yip TC, Chow EY, Kwok R, Lee HW, Wong GL, Ma RC, Chan HL, Wong VW, Chan JC. Diabetes Res Clin Pract. 2023 Aug;202:110825. doi: 10.1016/j.diabres.2023.110825.

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Editorial: Will MRI-PDFF become the new standard for steatosis assessment in NAFLD? Authors’ reply.

Huang DQ, Loomba R. Aliment Pharmacol Ther. 2023 Aug;58(3):366-367. doi: 10.1111/apt.17619.

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AGA Clinical Practice Update on the Role of Noninvasive Biomarkers in the Evaluation and Management of Nonalcoholic Fatty Liver Disease: Expert Review.

Wattacheril JJ, Abdelmalek MF, Lim JK, Sanyal AJ. Gastroenterology. 2023 Aug 4:S0016-5085(23)00881-8. doi: 10.1053/j.gastro.2023.06.013.

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Confirmatory biomarker diagnostic studies are not needed when transitioning from NAFLD to MASLD.

Ratziu V, Boursier J; AFEF Group for the Study of Liver Fibrosis. J Hepatol. 2023 Aug 3:S0168-8278(23)04996-6. doi: 10.1016/j.jhep.2023.07.017.

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Emerging concepts in the detection of liver fibrosis in non-alcoholic fatty liver disease.

Armandi A, Michel M, Gjini K, Emrich T, Bugianesi E, Schattenberg JM. Expert Rev Mol Diagn. 2023 Aug 1:1-12. doi: 10.1080/14737159.2023.2242779.

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Hepatic, Extra-hepatic Outcomes and Causes of Mortality in NAFLD – An Umbrella Overview of Systematic Review of Meta-Analysis.

Xiao J, Ng CH, Chan KE, Fu C, Tay P, Yong JN, Lim WH, Tan DJH, Syn N, Wong ZY, Tseng M, Chew N, Huang DQ, Dan YY, Wong VWLoomba R, Siddiqui MS, Sanyal AJ, Noureddin M, Muthiah MD. J Clin Exp Hepatol. 2023 Jul-Aug;13(4):656-665. doi: 10.1016/j.jceh.2022.11.006.

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Alterations of hepatic energy metabolism in murine models of obesity, diabetes and fatty liver diseases.

Dewidar B, Mastrototaro L, Englisch C, Ress C, Granata C, Rohbeck E, Pesta D, Heilmann G, Wolkersdorfer M, Esposito I, Reina Do Fundo M, Zivehe F, Yavas A, Roden M. EBioMedicine. 2023 Aug;94:104714. doi: 10.1016/j.ebiom.2023.104714.

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At the dawn of potent therapeutics for fatty liver disease – introducing the miniseries on promising pharmacological targets for NASH.

Ratziu V, Tacke F. J Hepatol. 2023 Aug;79(2):261-262. doi: 10.1016/j.jhep.2023.04.003.

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A global action agenda for turning the tide on fatty liver disease.

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The effects of extracellular vesicles and their cargo on metabolism and its adaptation to physical exercise in insulin resistance and type 2 diabetes.

Mastrototaro L, Roden M. Proteomics. 2023 Jul 31:e2300078. doi: 10.1002/pmic.202300078.

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Serum identification of At-Risk MASH: The Metabolomics-Advanced steatohepatitis fibrosis score (MASEF).

Noureddin M, Truong E, Mayo R, Martínez-Arranz I, Mincholé I, Banales JM, Arrese M, Cusi K, Arias-Loste MT, Bruha R, Romero-Gómez M, Iruzubieta P, Aller R, Ampuero J, Calleja JL, Ibañez-Samaniego L, Aspichueta P, Marín-Duce A, Kushner T, Ortiz P, Harrison SA, Anstee QM, Crespo J, Mato JM, Sanyal AJ. Hepatology. 2023 Jul 24. doi: 10.1097/HEP.0000000000000542.

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Global prevalence of non-alcoholic fatty liver disease in type 2 diabetes mellitus: an updated systematic review and meta-analysis.

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Emerging advances in the pharmacologic treatment of nonalcoholic steatohepatitis and related cirrhosis

Sinakos E, Liava C, Loomba R. Ann Gastroenterol. 2022 May-Jun;35(3):213-225. doi: 10.20524/aog.2022.0704.

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American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings: Co-Sponsored by the American Association for the Study of Liver Diseases (AASLD)

Cusi K, Isaacs S, Barb D, Basu R, Caprio S, Garvey WT, Kashyap S, Mechanick JI, Mouzaki M, Nadolsky K, Rinella ME, Vos MB, Younossi Z. Endocr Pract. 2022 May;28(5):528-562. doi: 10.1016/j.eprac.2022.03.010.

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NAFLD/NASH

Bugianesi E, Petta S. J Hepatol. 2022 May 2:S0168-8278(22)00081-2. doi: 10.1016/j.jhep.2022.02.006.

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American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings: Co-Sponsored by the American Association for the Study of Liver Diseases (AASLD)

Cusi K, Isaacs S, Barb D, Basu R, Caprio S, Garvey WT, Kashyap S, Mechanick JI, Mouzaki M, Nadolsky K, Rinella ME, Vos MB, Younossi Z. Endocr Pract. 2022 May;28(5):528-562. doi: 10.1016/j.eprac.2022.03.010.

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Mortality Outcomes by Fibrosis Stage in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis

Ng CH, Lim WH, Hui Lim GE, Hao Tan DJ, Syn N, Muthiah MD, Huang DQ, Loomba R. Clin Gastroenterol Hepatol. 2022 May 2:S1542-3565(22)00439-6. doi: 10.1016/j.cgh.2022.04.014.

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Response to: “Nonalcoholic fatty liver disease in diabetes: Overlooked or just ignored?”

Barb D, Cusi K. Obesity (Silver Spring). 2022 May;30(5):971-972. doi: 10.1002/oby.23422.

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Adipose tissue measurement in clinical research for obesity, type 2 diabetes and NAFLD/NASH

Vilalta A, Gutiérrez JA, Chaves S, Hernández M, Urbina S, Hompesch M. Endocrinol Diabetes Metab. 2022 May;5(3):e00335. doi: 10.1002/edm2.335.

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A global view of the interplay between non-alcoholic fatty liver disease and diabetes.

Stefan N, Cusi K. Lancet Diabetes Endocrinol. 2022 Apr;10(4):284-296. doi: 10.1016/S2213-8587(22)00003-1.

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Impaired Hepatic Mitochondrial Capacity in Nonalcoholic Steatohepatitis Associated With Type 2 Diabetes.

Gancheva S, Kahl S, Pesta D, Mastrototaro L, Dewidar B, Strassburger K, Sabah E, Esposito I, Weiß J, Sarabhai T, Wolkersdorfer M, Fleming T, Nawroth P, Zimmermann M, Reichert AS, Schlensak M, Roden M. Diabetes Care. 2022 Apr 1;45(4):928-937. doi: 10.2337/dc21-1758.

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Comparative efficacy of an optimal exam between ultrasound versus abbreviated MRI for HCC screening in NAFLD cirrhosis: A prospective study.

Huang DQ, Fowler KJ, Liau J, Cunha GM, Louie AL, An JY, Bettencourt R, Jung J, Gitto Z, Hernandez C, Lopez SJ, Gupta H, Sirlin CB, Marks RM, Loomba R. Aliment Pharmacol Ther. 2022 Apr;55(7):820-827. doi: 10.1111/apt.16844.

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A nutrigenetic tool for precision dietary management of NAFLD deeming insulin resistance markers

Perez-Diaz-Del-Campo N, Riezu-Boj JI, Marin-Alejandre BA, Monreal JI, Elorz M, Herrero JI, Benito-Boillos A, Milagro FI, Bugianesi E, Tur JA, Martinez JA, Abete I, Zulet MA. Panminerva Med. 2022 Apr 19. doi: 10.23736/S0031-0808.22.04590-6.

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Redefinition of Fatty Liver Disease from NAFLD to MAFLD through the Lens of Drug Development and Regulatory Science

Fouad Y, Palmer M, Chen M, Regev A, Banerjee R, Myers R, Riccio R, Torstenson R, Younes R, Arora PS, Landgren H, Karsdal MA, Blake M, Shapiro DA, Gruss HJ, Sheikh MY, Attia D, Bollipo S, Smith AD, Freilich B, Gish RG, Schuppan D. J Clin Transl Hepatol. 2022 Apr 28;10(2):374-382. doi: 10.14218/JCTH.2021.00408.

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Greater ectopic fat deposition and liver fibroinflammation, and lower skeletal muscle mass in people with type 2 diabetes

Waddell T, Bagur A, Cunha D, Thomaides-Brears H, Banerjee R, Cuthbertson DJ, Brown E, Cusi K, Després JP, Brady M. Obesity (Silver Spring). 2022 Apr 27. doi: 10.1002/oby.23425.

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Risk of liver-related events by age and diabetes duration in diabetic patients with non-alcoholic fatty liver disease.

Zhang X, Wong GL, Yip TC, Cheung JTK, Tse YK, Hui VW, Lin H, Lai JC, Chan HL, Kong AP, Wong VW. Hepatology. 2022 Mar 25. doi: 10.1002/hep.32476.

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Direct Comparison of Quantitative US versus Controlled Attenuation Parameter for Liver Fat Assessment Using MRI Proton Density Fat Fraction as the Reference Standard in Patients Suspected of Having NAFLD.

Jung J, Han A, Madamba E, Bettencourt R, Loomba RR, Boehringer AS, Andre MP, Erdman JW Jr, O'Brien WD Jr, Fowler KJ, Sirlin CB, Loomba R. Radiology. 2022 Mar 29:211131. doi: 10.1148/radiol.211131.

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Noninvasive assessment of liver fibrosis and its clinical significance in nonalcoholic fatty liver disease.

Tamaki N, Kurosaki M, Huang DQ, Loomba R. Hepatol Res. 2022 Mar 30. doi: 10.1111/hepr.13764.

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Non-Alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet.

Cusi K. J Clin Endocrinol Metab. 2022 Mar 25:dgac186. doi: 10.1210/clinem/dgac186.

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A Simple Test to Identify the Risk of NASH and Cirrhosis in People with Obesity or Diabetes: The Time to Screen is Now.

Cusi K. J Clin Endocrinol Metab. 2022 Mar 25:dgac186. doi: 10.1210/clinem/dgac186.

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Reliability of Histologic Assessment for NAFLD and Development of an Expanded NAFLD Activity Score.

Pai RK, Jairath V, Hogan M, Zou G, Adeyi OA, Anstee QM, Aqel BA, Behling C, Carey EJ, Clouston AD, Corey K, Feagan BG, Kleiner DE, Ma C, McFarlane SC, Noureddin M, Ratziu V, Valasek MA, Younossi ZM, Harrison SA, Loomba R. Hepatology. 2022 Mar 25. doi: 10.1002/hep.32475.

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Aldafermin in patients with non-alcoholic steatohepatitis (ALPINE 2/3): a randomised, double-blind, placebo-controlled, phase 2b trial.

Harrison SA, Abdelmalek MF, Neff G, Gunn N, Guy CD, Alkhouri N, Bashir MR, Freilich B, Kohli A, Khazanchi A, Sheikh MY, Leibowitz M, Rinella ME, Siddiqui MS, Kipnes M, Moussa SE, Younes ZH, Bansal M, Baum SJ, Borg B, Ruane PJ, Thuluvath PJ, Gottwald M, Khan M, Chen C, Melchor-Khan L, Chang W, DePaoli AM, Ling L, Lieu HD. Lancet Gastroenterol Hepatol. 2022 Mar 21:S2468-1253(22)00017-6. doi: 10.1016/S2468-1253(22)00017-6.

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Is lean non-alcoholic fatty liver disease a distinct entity?

Lin H, Wong VW. Hepatol Int. 2022 Mar 24. doi: 10.1007/s12072-022-10324-9.

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Systematic review and meta-analysis: analysis of variables influencing the interpretation of clinical trial results in NAFLD.

Ampuero J, Gallego-Durán R, Maya-Miles D, Montero R, Gato S, Rojas Á, Gil A, Muñoz R, Romero-Gómez M. J Gastroenterol. 2022 Mar 24. doi: 10.1007/s00535-022-01860-0.

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Meta-analysis: analysis of mechanistic pathways in the treatment of non-alcoholic steatohepatitis. Evidence from a Bayesian network meta-analysis.

Ng CH, Muthiah MD, Xiao J, Chin YH, Lim G, Lim WH, Tay P, Tan DJH, Yong JN, Pan XH, Koh JWH, Chew N, Syn N, Tan E, Huang DQ, Siddiqui MS, Loomba R, Sanyal AJ, Noureddin M. Aliment Pharmacol Ther. 2022 Mar 14. doi: 10.1111/apt.16808.

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Clinical Interest of Serum Alpha-2 Macroglobulin, Apolipoprotein A1, and Haptoglobin in Patients with Non-Alcoholic Fatty Liver Disease, with and without Type 2 Diabetes, before or during COVID-19.

Deckmyn O, Poynard T, Bedossa P, Paradis V, Peta V, Pais R, Ratziu V, Thabut D, Brzustowski A, Gautier JF, Cacoub P, Valla D. Biomedicines. 2022 Mar 17;10(3):699. doi: 10.3390/biomedicines10030699.

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Comparison of clinical prediction rules for ruling out cirrhosis in nonalcoholic fatty liver disease (NAFLD).

Brandman D, Boyle M, McPherson S, Van Natta ML, Sanyal AJ, Kowdley K, Neuschwander-Tetri B, Chalasani N, Abdelmalek MF, Terrault NA, McCullough A, Bettencourt R, Caussy C, Kleiner DE, Behling C, Tonascia J, Anstee QM, Loomba R; Members of the Nonalcoholic Steatohepatitis Clinical Research Network. Aliment Pharmacol Ther. 2022 Mar 17. doi: 10.1111/apt.16874.

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Clinical characteristics, surveillance, treatment allocation, and outcomes of non-alcoholic fatty liver disease-related hepatocellular carcinoma: a systematic review and meta-analysis.

Tan DJH, Ng CH, Lin SY, Pan XH, Tay P, Lim WH, Teng M, Syn N, Lim G, Yong JN, Quek J, Xiao J, Dan YY, Siddiqui MS, Sanyal AJ, Muthiah MD, Loomba R, Huang DQ. Lancet Oncol. 2022 Mar 4:S1470-2045(22)00078-X. doi: 10.1016/S1470-2045(22)00078-X.

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Variation in Alanine Aminotransferase in Children with Non-Alcoholic Fatty Liver Disease.

Castillo-Leon E, Morris HL, Schoen C, Bilhartz J, McKiernan P, Miloh T, Palle S, Kabbany MN, Munoz B, Mospan AR, Rudolph B, Xanthakos SA, Vos MB, Target-Nash Investigators. Children (Basel). 2022 Mar 8;9(3):374. doi: 10.3390/children9030374.

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Meta-analysis: Prevalence of, and risk factors for, non-alcoholic fatty liver disease in patients with inflammatory bowel disease.

Zamani M, Alizadeh-Tabari S, Singh S, Loomba R. Aliment Pharmacol Ther. 2022 Mar 11. doi: 10.1111/apt.16879.

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NAFLD increases Risk of Carotid Atherosclerosis and Ischemic Stroke. An Updated Meta-Analysis with 135,602 Individuals.

Tang ASP, Chan KE, Quek J, Xiao J, Tay P, Teng M, Lee KS, Lin SY, Myint MZ, Tan B, Sharma VK, Tan DJH, Lim WH, Kaewdech A, Huang D, Chew NW, Siddiqui MS, Sanyal AJ, Muthiah M, Ng CH. Clin Mol Hepatol. 2022 Mar 2. doi: 10.3350/cmh.2021.0406.

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Global multi-stakeholder endorsement of the MAFLD definition.

Méndez-Sánchez N, Bugianesi E, Gish RG, Lammert F, Tilg H, Nguyen MH, Sarin SK, Fabrellas N, Zelber-Sagi S, Fan JG, Shiha G, Targher G, Zheng MH, Chan WK, Vinker S, Kawaguchi T, Castera L, Yilmaz Y, Korenjak M, Spearman CW, Ungan M, Palmer M, El-Shabrawi M, Gruss HJ, Dufour JF, Dhawan A, Wedemeyer H, George J, Valenti L, Fouad Y, Romero-Gomez M, Eslam M; Global multi-stakeholder consensus on the redefinition of fatty liver disease. Lancet Gastroenterol Hepatol. 2022 Mar 3:S2468-1253(22)00062-0. doi: 10.1016/S2468-1253(22)00062-0.

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A cholestatic pattern predicts major liver-related outcomes in patients with non-alcoholic fatty liver disease.

Pennisi G, Pipitone RM, Cabibi D, Enea M, Romero-Gomez M, Viganò M, Bugianesi E, Wong VW, Fracanzani AL, Sebastiani G, Berzigotti A, Di Salvo F, Giannone AG, La Mantia C, Lupo G, Porcasi R, Vernuccio F, Zito R, Di Marco V, Cammà C, Craxì A, de Ledinghen V, Grimaudo S, Petta S. Liver Int. 2022 Mar 4. doi: 10.1111/liv.15232.

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Liver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation.

Gallego-Durán R, Ampuero J, Pastor-Ramírez H, Álvarez-Amor L, Del Campo JA, Maya-Miles D, Montero-Vallejo R, Cárdenas-García A, Pareja MJ, Gato-Zambrano S, Millán R, Del Carmen Rico M, Luque-Sierra A, Gil-Gómez A, Rojas Á, Muñoz-Hernández R, García-Lozano M, Aller R, Andrade RJ, García-Monzón C, Andreola F, Martín F, Jalan R, Romero-Gómez M. Sci Rep. 2022 Mar 1;12(1):3418. doi: 10.1038/s41598-022-06614-9.

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Association of Obesity, Diabetes, and Alcohol Use With Liver Fibrosis Among US Adults With Hepatitis C Virus Infection.

Migdal AL, Jagannathan R, Qayed E, Cusi K, McCoy RG, Pasquel FJ, Miller LS. JAMA Netw Open. 2022 Mar 1;5(3):e2142282. doi: 10.1001/jamanetworkopen.2021.42282.

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Non-Invasive Biomarkers of Nonalcoholic Steatohepatitis: the FNIH NIMBLE project.

Sanyal AJ, Shankar SS, Calle RA, Samir AE, Sirlin CB, Sherlock SP, Loomba R, Fowler KJ, Dehn CA, Heymann H, Kamphaus TN. Nat Med. 2022 Mar;28(3):430-432. doi: 10.1038/s41591-021-01652-8.

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Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease

McGlinchey AJ, Govaere O, Geng D, Ratziu V, Allison M, Bousier J, Petta S, de Oliviera C, Bugianesi E, Schattenberg JM, Daly AK, Hyötyläinen T, Anstee QM, Orešič M. JHEP Rep. 2022 Mar 26;4(5):100477. doi: 10.1016/j.jhepr.2022.100477.

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JCL Roundtable. Obesity, Diabetes, and Liver Disease in Relation to Cardiovascular Risk

Wyne KL, Litwin SE, Cusi K, Guyton JR. J Clin Lipidol. 2022 Mar-Apr;16(2):115-127. doi: 10.1016/j.jacl.2022.03.007.

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Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles.

Martínez-Arranz I, Bruzzone C, Noureddin M, Gil-Redondo R, Mincholé I, Bizkarguenaga M, Arretxe E, Iruarrizaga-Lejarreta M, Fernández-Ramos D, Lopitz-Otsoa F, Mayo R, Embade N, Newberry E, Mittendorf B, Izquierdo-Sánchez L, Smid V, Arnold J, Iruzubieta P, Pérez Castaño Y, Krawczyk M, Marigorta UM, Morrison MC, Kleemann R, Martín-Duce A, Hayardeny L, Vitek L, Bruha R, Aller de la Fuente R, Crespo J, Romero-Gomez M, Banales JM, Arrese M, Cusi KBugianesi E, Klein S, Lu SC, Anstee QM, Millet O, Davidson NO, Alonso C, Mato JM. Hepatology. 2022 Feb 26. doi: 10.1002/hep.32427.

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Nonalcoholic steatohepatitis is the most common indication for liver transplantation among the elderly: Data from the United States Scientific Registry of Transplant Recipients.

Stepanova M, Kabbara K, Mohess D, Verma M, Roche-Green A, AlQahtani S, Ong J, Burra P, Younossi ZM. Hepatol Commun. 2022 Feb 28. doi: 10.1002/hep4.1915.

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Differential fuel utilization in liver transplant recipients and its relationship with non-alcoholic fatty liver disease.

Siddiqui MS, Patel S, Forsgren M, Bui AT, Shen S, Syed T, Boyett S, Chen S, Sanyal AJ, Wolver S, Kirkman D, Celi FS, Bhati CS. Liver Int. 2022 Feb 7. doi: 10.1111/liv.15178.

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Factors Impacting Survival in Those Transplanted for NASH Cirrhosis: Data From the NailNASH Consortium.

Rinella ME, Satapathy SK, Brandman D, Smith C, Elwir S, Xia J, Gibson M, Figueredo C, Angirekula M, Vanatta JM, Sarwar R, Jiang Y, Gregory D, Agostini T, Ko J, Podila P, Gallo G, Watt KD, Siddiqui MS. Clin Gastroenterol Hepatol. 2022 Feb 18:S1542-3565(22)00184-7. doi: 10.1016/j.cgh.2022.02.028.

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Dual roles of B lymphocytes in mouse models of diet-induced nonalcoholic fatty liver disease.

Karl M, Hasselwander S, Zhou Y, Reifenberg G, Kim YO, Park KS, Ridder DA, Wang X, Seidel E, Hövelmeyer N, Straub BK, Li H, Schuppan D, Xia N. Hepatology. 2022 Feb 26. doi: 10.1002/hep.32428.

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Two-Step Strategy, FIB-4 Followed by Magnetic Resonance Elastography, for Detecting Advanced Fibrosis in NAFLD.

Tamaki N, Imajo K, Sharpton SR, Jung J, Sutter N, Kawamura N, Yoneda M, Valasek MA, Behling C, Sirlin CB, Kurosaki M, Izumi N, Nakajima A, Loomba R. Clin Gastroenterol Hepatol. 2022 Feb 2:S1542-3565(22)00077-5. doi: 10.1016/j.cgh.2022.01.023.

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Meaning of non-overlapping patients between the MAFLD and NAFLD definitions.

Chan WK, Wong VW. Liver Int. 2022 Feb;42(2):271-273. doi: 10.1111/liv.15142.

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Fatty Liver Through the Ages: Nonalcoholic Steatohepatitis.

Younossi ZM, Henry L. Endocr Pract. 2022 Feb;28(2):204-213. doi: 10.1016/j.eprac.2021.12.010. Epub 2021 Dec 22.

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Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance.

Johnson K, Leary PJ, Govaere O, Barter MJ, Charlton SH, Cockell SJ, Tiniakos D, Zatorska M, Bedossa P, Brosnan MJ, Cobbold JF, Ekstedt M, Aithal GP, Clément K, Schattenberg JM, Boursier J, Ratziu VBugianesi E, Anstee QM, Daly AK; LITMUS Consortium Investigators; LITMUS Consortium Investigators. JHEP Rep. 2021 Nov 25;4(2):100409. doi: 10.1016/j.jhepr.2021.100409. eCollection 2022 Feb.

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Magnetic Resonance Elastography for the Clinical Risk Assessment of Fibrosis, Cirrhosis, and Portal Hypertension in Patients With NAFLD.

Natarajan Y, Loomba R. J Clin Exp Hepatol. 2022 Jan-Feb;12(1):174-179. doi: 10.1016/j.jceh.2021.08.002.

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Non-invasive methods for imaging hepatic steatosis and their clinical importance in NAFLD.

Tamaki N, Ajmera V, Loomba R. Nat Rev Endocrinol. 2022 Jan;18(1):55-66. doi: 10.1038/s41574-021-00584-0.

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Non-obese non-alcoholic fatty liver disease (NAFLD) in Asia: an international registry study.

Tan EX, Lee JW, Jumat NH, Chan WK, Treeprasertsuk S, Goh GB, Fan JG, Song MJ, Charatcharoenwitthaya P, Duseja A, Imajo K, Nakajima A, Seki Y, Kasama K, Kakizaki S, Lesmana LA, Zheng KI, Zheng MH, Koh CJ, Ho KY, Goh KL, Wong VW, Dan YY. Metabolism. 2022 Jan;126:154911. doi: 10.1016/j.metabol.2021.154911.

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Hepatocyte-Specific Deletion of HIF2α Prevents NASH-Related Liver Carcinogenesis by Decreasing Cancer Cell Proliferation.

Foglia B, Sutti S, Cannito S, Rosso C, Maggiora M, Autelli R, Novo E, Bocca C, Villano G, Ramavath NN, Younes R, Tusa I, Rovida E, Pontisso P, Bugianesi E, Albano E, Parola M. Cell Mol Gastroenterol Hepatol. 2021 Oct 14:S2352-345X(21)00216-2. doi: 10.1016/j.jcmgh.2021.10.002.

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Clinicopathological Profile and Outcome of a Large Cohort of Patients with Nonalcoholic Fatty Liver Disease from South Asia: Interim Results of the Indian Consortium on Nonalcoholic Fatty Liver Disease.

Duseja A, Singh SP, Mehta M, Shalimar, Venkataraman J, Mehta V, Devadas K, Kar SK, Goyal O, Nagral A, Saigal S, Nijhawan S, Praharaj D, Shukla A, Sharma B, Narayanasamy K, Kumar P, Rao PN, Arora A, Mehta R, Asati P, Ranjan P, Koshy A, Alam S, Mukewar S, Mukewar S, Mohan Prasad VG, Rastogi M, Sanyal AJ. Metab Syndr Relat Disord. 2022 Jan 25. doi: 10.1089/met.2021.0104.

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Long-Term Effects of the Changes in Hepatic Steatosis Status on the Risk of Incident Type 2 Diabetes Mellitus: a 15-Year Community-Based Prospective Cohort Study.

Min Chung S, Kyu Kang M, Jung J, Sung Yoon J, Chang Won K, Woo Lee H, Loomba R, Gil Park J, Sung Moon J. Diabetes Res Clin Pract. 2022 Jan 18:109208. doi: 10.1016/j.diabres.2022.109208.

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Oncostatin M is overexpressed in NASH-related hepatocellular carcinoma and promotes cancer cell invasiveness and angiogenesis.

Di Maira G, Foglia B, Napione L, Turato C, Maggiora M, Sutti S, Novo E, Alvaro M, Autelli R, Colombatto S, Bussolino F, Carucci P, Gaia S, Rosso C, Biasiolo A, Pontisso P, Bugianesi E, Albano E, Marra F, Parola M, Cannito S. J Pathol. 2022 Jan 22. doi: 10.1002/path.5871.

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Derivation and validation of the NAFLD Cirrhosis Score (NCS) to distinguish bridging fibrosis from cirrhosis.

Labenz C, Toenges G, Zheng MH, Ding D, Myers RP, Galle PR, Armandi A, Ampuero J, Gómez MR, Bugianesi E, Anstee QM, Schattenberg JM. Eur J Intern Med. 2022 Jan 17:S0953-6205(21)00413-1. doi: 10.1016/j.ejim.2021.12.011.

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Non-invasive tests accurately stratify patients with NAFLD based on their risk of liver-related events.

Boursier J, Hagström H, Ekstedt M, Moreau C, Bonacci M, Cure S, Ampuero J, Nasr P, Tallab L, Canivet CM, Kechagias S, Sánchez Y, Dincuff E, Lucena A, Roux M, Riou J, Trylesinski A, Romero-Gomez M. J Hepatol. 2022 Jan 18:S0168-8278(22)00002-2. doi: 10.1016/j.jhep.2021.12.031.

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Liver-related and extrahepatic events in patients with non-alcoholic fatty liver disease: a retrospective competing risks analysis.

Pennisi G, Enea M, Romero-Gomez M, Viganò M, Bugianesi E, Wong VW, Fracanzani AL, Sebastiani G, Boursier J, Berzigotti A, Eslam M, Ampuero J, Benmassaoud A, La Mantia C, Mendoza YP, George J, Craxì A, Camma' C, de Ledinghen V, Petta S. Aliment Pharmacol Ther. 2022 Jan 5. doi: 10.1111/apt.16763.

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Placebo effect on progression and regression in NASH: Evidence from a meta-analysis.

Ng CH, Xiao J, Lim WH, Chin YH, Yong JN, Tan DJH, Tay P, Syn N, Foo R, Chan M, Chew N, Tan EX, Huang DQ, Dan YY, Tamaki N, Siddiqui MS, Sanyal AJLoomba R, Noureddin M, Muthiah MD. Hepatology. 2022 Jan 6. doi: 10.1002/hep.32315.

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NASHFit: of an exercise training program to reduce clotting risk in patients with NASH.

Stine JG, Schreibman IR, Faust AJ, Dahmus J, Stern B, Soriano C, Rivas G, Hummer B, Kimball SR, Geyer NR, Chinchilli VM, Loomba R, Schmitz K, Sciamanna C. Hepatology. 2021 Dec 10. doi: 10.1002/hep.32274.

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The global NAFLD policy review and preparedness index: Are countries ready to address this silent public health challenge?

Lazarus JV, Mark HE, Villota-Rivas M, Palayew A, Carrieri P, Colombo M, Ekstedt M, Esmat G, George J, Marchesini G, Novak K, Ocama P, Ratziu V, Razavi H, Romero-Gómez M, Silva M, Spearman CW, Tacke F, Tsochatzis EA, Yilmaz Y, Younossi ZM, Wong VW, Zelber-Sagi S, Cortez-Pinto H, Anstee QM; NAFLD policy review collaborators. J Hepatol. 2021 Dec 8:S0168-8278(21)02168-1. doi: 10.1016/j.jhep.2021.10.025.

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Elevated liver enzymes and comorbidities in type 2 diabetes: Multicenter analysis of 51,645 patients of the DPV database.

Meyhöfer S, Eckert AJ, Hummel M, Laimer M, Roden M, Kress S, Seufert J, Meyhöfer SM, Holl RW. Diabetes Obes Metab. 2021 Dec 9. doi: 10.1111/dom.14616. Online ahead of print.PMID: 34882949 

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Comparative diagnostic performance of ultrasound shear wave elastography and magnetic resonance elastography for classifying fibrosis stage in adults with biopsy-proven nonalcoholic fatty liver disease.

Zhang YN, Fowler KJ, Boehringer AS, Montes V, Schlein AN, Covarrubias Y, Wolfson T, Hong CW, Valasek MA, Andre MP, Loomba R, Sirlin CB. Eur Radiol. 2021 Dec 2. doi: 10.1007/s00330-021-08369-9.

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An Observational Data Meta-Analysis on the Differences in Prevalence and Risk Factors Between MAFLD vs NAFLD.

Hui Lim GE, Tang A, Ng CH, Chin YH, Lim WH, Hao Tan DJ, Yong JN, Xiao J, Wen-Min Lee C, Chan M, Chew NW, Xuan Tan EX, Siddiqui MS, Huang D, Noureddin M, Sanyal AJ, Muthiah MD. Clin Gastroenterol Hepatol. 2021 Dec 3:S1542-3565(21)01276-3. doi: 10.1016/j.cgh.2021.11.038.

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Evaluation of a Stepped Care Approach to Manage Depression and Diabetes Distress in Patients with Type 1 Diabetes and Type 2 Diabetes: Results of a Randomized Controlled Trial (ECCE HOMO Study).

Schmitt A, Kulzer B, Reimer A, Herder C, Roden M, Haak T, Hermanns N. Psychother Psychosom. 2021 Dec 7:1-16. doi: 10.1159/000520319.

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The EASL-Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality.

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Huang DQ, El-Serag HB, Loomba R. Nat Rev Gastroenterol Hepatol. 2020 Dec 21. doi: 10.1038/s41575-020-00381-6.

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Macrophage Markers Do Not Add to the Prediction of Liver Fibrosis by Transient Elastography in Patients With Metabolic Associated Fatty Liver Disease.

Kazankov K, Rosso C, Younes R, Armandi A, Hagström H, Møller HJ, Stål P, Bugianesi E, Grønbæk H. Front Med (Lausanne). 2020 Dec 18;7:616212. doi: 10.3389/fmed.2020.616212.

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Development of a Patient-Reported Outcome Measure for Non-Alcoholic Steatohepatitis (NASH-CHECK): Results of a Qualitative Study.

Doward LC, Balp MM, Twiss J, Slota C, Cryer D, Brass CA, Anstee QM, Sanyal AJ. Patient. 2020 Dec 18. doi: 10.1007/s40271-020-00485-w.

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Disease severity predicts higher healthcare costs among hospitalized nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH) patients in Spain.

Romero-Gomez M, Kachru N, Zamorano MA, Darba J, Shreay S. Medicine (Baltimore). 2020 Dec 11;99(50):e23506. doi: 10.1097/MD.0000000000023506.

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Genetic variation in the TLL1 gene is not associated with fibrosis in patients with metabolic associated fatty liver disease.

Bayoumi A, Jalil I, Metwally M, Adams LA, Aller R, García-Monzón C, Arias-Loste MT, Miele L, Petta S, Craxì A, Gallego-Durán R, Fischer J, Berg T, Qiao L, Liddle C, Bugianesi E, Romero-Gomez M, George J, Eslam M. PLoS One. 2020 Dec 11;15(12):e0243590. doi: 10.1371/journal.pone.0243590.

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AGA Clinical Practice Update on Lifestyle Modification Using Diet and Exercise to Achieve Weight Loss in the Management of Nonalcoholic Fatty Liver Disease: Expert Review.

Younossi ZM, Corey KE, Lim JK. Gastroenterology. 2020 Dec 9:S0016-5085(20)35538-4. doi: 10.1053/j.gastro.2020.11.051.

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Disease severity predicts higher healthcare costs among hospitalized nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH) patients in Spain.

Romero-Gomez M, Kachru N, Zamorano MA, Darba J, Shreay S. Medicine (Baltimore). 2020 Dec 11;99(50):e23506. doi: 10.1097/MD.0000000000023506.

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Inhibition of fatty acid synthase with FT-4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with NAFLD non-alcoholic fatty liver disease: results from two early phase randomized trials.

Beysen C, Schroeder P, Wu E, Brevard J, Ribadeneira M, Lu W, Dole K, O'Reilly TE, Morrow L, Hompesch M, Hellerstein MK, Li K, Johansson L, Kelly PF. Diabetes Obes Metab. 2020 Dec 2. doi: 10.1111/dom.14272.

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The Association of Histologic and Non-invasive Tests with Adverse Clinical and Patient-Reported Outcomes in Patients with Advanced Fibrosis Due to Nonalcoholic Steatohepatitis (NASH).

Younossi ZM, Anstee QM, Wai-Sun Wong V, Trauner M, Lawitz EJ, Harrison SA, Camargo M, Kersey K, Subramanian GM, Myers RP, Stepanova M. Gastroenterology. 2020 Dec 8:S0016-5085(20)35529-3. doi: 10.1053/j.gastro.2020.12.003.

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Non-alcoholic fatty liver disease: Not time for an obituary just yet!

Singh SP, Anirvan P, Reddy KR, Conjeevaram HS, Marchesini G, Rinella ME, Madan K, Petroni ML, Al-Mahtab M, Caldwell SH, Aithal GP, Hamid SS, Farrell GC, Satapathy SK, Duseja A, Acharya SK, Dassanayake AS, Goh KL. J Hepatol. 2020 Dec 16:S0168-8278(20)33729-6. doi: 10.1016/j.jhep.2020.10.015.

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Association between gut permeability and insulin resistance: Any role for zonulin in patients with non-alcoholic fatty liver disease?

Singh SP, Anirvan P, Reddy KR, Conjeevaram HS, Marchesini G, Rinella ME, Madan K, Petroni ML, Al-Mahtab M, Caldwell SH, Aithal GP, Hamid SS, Farrell GC, Satapathy SK, Duseja A, Acharya SK, Dassanayake AS, Goh KL. J Hepatol. 2020 Dec 16:S0168-8278(20)33729-6. doi: 10.1016/j.jhep.2020.10.015.

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Sex Hormone Relations to Histologic Severity of Pediatric Nonalcoholic Fatty Liver Disease.

Mueller NT, Liu T, Mitchel EB, Yates KP, Suzuki A, Behling C, Lavine JE. J Clin Endocrinol Metab. 2020 Nov 1;105(11):dgaa574. doi: 10.1210/clinem/dgaa574.

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A Sequential Algorithm Combining ADAPT and Liver Stiffness Can Stage Metabolic-Associated Fatty Liver Disease in Hospital-Based and Primary Care Patients.

Eslam M, Wong GL, Hashem AM, Chan HL, Nielsen MJ, Leeming DJ, Chan AW, Chen Y, Duffin KL, Karsdal M, Schattenberg JM, George J, Wong VW. Am J Gastroenterol. 2020 Nov 26. doi: 10.14309/ajg.0000000000001059.

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Early changes in hepatic energy metabolism and lipid content in recent-onset type 1 and 2 diabetes mellitus.

Kupriyanova Y, Zaharia OP, Bobrov P, Karusheva Y, Burkart V, Szendroedi J, Hwang JH, Roden M; GDS group. J Hepatol. 2020 Nov 28:S0168-8278(20)33817-4. doi: 10.1016/j.jhep.2020.11.030.

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Overall clinical and economic impact of non-alcoholic fatty liver disease.

Sicras-Mainar A, Aller R, Crespo J, Calleja JL, Turnes J, Romero-Gómez M, Augustín S. Rev Esp Enferm Dig. 2020 Nov 23. doi: 10.17235/reed.2020.7238/2020.

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Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores.

Bianco C, Jamialahmadi O, Pelusi S, Baselli G, Dongiovanni P, Zanoni I, Santoro L, Maier S, Liguori A, Meroni M, Borroni V, D'Ambrosio R, Spagnuolo R, Alisi A, Federico A, Bugianesi E, Petta S, Miele L, Vespasiani-Gentilucci U, Anstee QM, Stickel F, Hampe J, Fischer J, Berg T, Fracanzani AL, Soardo G, Reeves H, Prati D, Romeo S, Valenti L.J Hepatol. 2020 Nov 25:S0168-8278(20)33811-3. doi: 10.1016/j.jhep.2020.11.024.

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MRE combined with FIB-4 (MEFIB) index in detection of candidates for pharmacological treatment of NASH-related fibrosis.

Jung J,Loomba RR, Imajo K, Madamba E, Gandhi S, Bettencourt R, Singh S, Hernandez C, Valasek MA, Behling C, Richards L, Fowler K, Sirlin CB, Nakajima A, Loomba R. Gut. 2020 Nov 19:gutjnl-2020-322976. doi: 10.1136/gutjnl-2020-322976.

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Interplay between Oxidative Stress and Metabolic Derangements in Non-Alcoholic Fatty Liver Disease: The Role of Selenoprotein P.

Caviglia GP, Rosso C, Armandi A, Gaggini M, Carli F, Abate ML, Olivero A, Ribaldone DG, Saracco GM, Gastaldelli A, Bugianesi E. Int J Mol Sci. 2020 Nov 22;21(22):E8838. doi: 10.3390/ijms21228838.

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A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis.

Newsome PN, Buchholtz K, Cusi K, Linder M, Okanoue T, Ratziu V, Sanyal AJ, Sejling AS, Harrison SA; NN9931-4296 Investigators. N Engl J Med. 2020 Nov 13. doi: 10.1056/NEJMoa2028395.

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Non-alcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans.

Pafili K, Roden M. Mol Metab. 2020 Nov 18:101122. doi: 10.1016/j.molmet.2020.101122.

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MRI-PDFF treatment response criteria in nonalcoholic steatohepatitis.

Loomba R. Hepatology. 2020 Nov 11. doi: 10.1002/hep.31624.

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Progression of Fatty Liver Disease in Children Receiving Standard of Care Lifestyle Advice.

Xanthakos SA, Lavine JE, Yates KP, Schwimmer JB, Molleston JP, Rosenthal P, Murray KF, Vos MB, Jain AK, Scheimann AO, Miloh T, Fishbein M, Behling CA, Brunt EM, Sanyal AJ, Tonascia J; NASH Clinical Research Network. Gastroenterology. 2020 Nov;159(5):1731-1751.e10. doi: 10.1053/j.gastro.2020.07.034.

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Combination therapies including cilofexor and firsocostat for bridging fibrosis and cirrhosis due to NASH.

Loomba R, Noureddin M, Kowdley KV, Kohli A, Sheikh A, Neff G, Bhandari BR, Gunn N, Caldwell SH, Goodman Z, Wapinski I, Resnick M, Beck AH, Ding D, Jia C, Chuang JC, Huss RS, Chung C, Subramanian GM, Myers RP, Patel K, Borg BB, Ghalib R, Kabler H, Poulos J, Younes Z, Elkhashab M, Hassanein T, Iyer R, Ruane P, Shiffman ML, Strasser S, Wong VW, Alkhouri N; ATLAS Investigators. Hepatology. 2020 Nov 10. doi: 10.1002/hep.31622.

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Clinical utility of change in nonalcoholic fatty liver disease activity score and change in fibrosis in NAFLD.

Tamaki N, Munaganuru N, Jung J, Yonan AQ, Bettencourt R, Ajmera V, Valasek MA, Behling C, Loomba R. Clin Gastroenterol Hepatol. 2020 Nov 3:S1542-3565(20)31518-4. doi: 10.1016/j.cgh.2020.11.005.

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A Phase 2 Double Blinded, Randomized Controlled Trial of Saroglitazar in Patients with Nonalcoholic Steatohepatitis.

Siddiqui MS, Idowu MO, Parmar D, Borg BB, Denham D, Loo NM, Lazas D, Younes Z, Sanyal AJ. Clin Gastroenterol Hepatol. 2020 Nov 2:S1542-3565(20)31509-3. doi: 10.1016/j.cgh.2020.10.051.

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The European NAFLD Registry: A real-world longitudinal cohort study of nonalcoholic fatty liver disease.

Hardy T, Wonders K, Younes R, Aithal GP, Aller R, Allison M, Bedossa P, Betsou F, Boursier J, Brosnan MJ, Burt A, Cobbold J, Cortez-Pinto H, Day CP, Dufour JF, Ekstedt M, Francque S, Harrison S, Miele L, Nasr P, Papatheodoridis G, Petta S, Tiniakos D, Torstenson R, Valenti L, Holleboom AG, Yki-Jarvinen H, Geier A, Romero-Gomez M, Ratziu V, Bugianesi E, Schattenberg JM, Anstee QM; LITMUS Consortium. Contemp Clin Trials. 2020 Oct 9;98:106175. doi: 10.1016/j.cct.2020.106175.

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3D analysis of microvasculature in murine liver fibrosis models using synchrotron radiation-based microtomography.

Wagner WL, Föhst S, Hock J, Kim YO, Popov Y, Schuppan D, Schladitz K, Redenbach C, Ackermann M. Angiogenesis. 2020 Oct 10. doi: 10.1007/s10456-020-09751-9.

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Expert Panel Review on Non-Alcoholic Fatty Liver Disease in Persons with HIV.

Lake JE, Overton T, Naggie S, Sulkowski M, Loomba R, Kleiner DE, Price JC, Chew KW, Chung RT, Corey KE. Clin Gastroenterol Hepatol. 2020 Oct 15:S1542-3565(20)31431-2. doi: 10.1016/j.cgh.2020.10.018.

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Semaglutide for the treatment of non-alcoholic steatohepatitis: Trial design and comparison of non-invasive biomarkers.

Harrison SA, Calanna S, Cusi K, Linder M, Okanoue T, Ratziu V, Sanyal A, Sejling AS, Newsome PN. Contemp Clin Trials. 2020 Oct 8:106174. doi: 10.1016/j.cct.2020.106174.

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Latin American Association for the study of the liver (ALEH) practice guidance for the diagnosis and treatment of non-alcoholic fatty liver disease.

Arab JP, Dirchwolf M, Álvares-da-Silva MR, Barrera F, Benítez C, Castellanos-Fernandez M, Castro-Narro G, Chavez-Tapia N, Chiodi D, Cotrim H, Cusi K, de Oliveira CPMS, Díaz J, Fassio E, Gerona S, Girala M, Hernandez N, Marciano S, Masson W, Mendez-Sanchez N, Leite N, Lozano A, Padilla M, Panduro A, Paraná R, Parise E, Perez M, Poniachik J, Restrepo JC, Ruf A, Silva M, Tagle M, Tapias M, Torres K, Vilar-Gomez E, Costa Gil JE, Gadano A, Arrese M. Ann Hepatol. 2020 Oct 5:S1665-2681(20)30177-0. doi: 10.1016/j.aohep.2020.09.006.

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In vivo absolute quantification of hepatic γ-ATP concentration in mice using 31 P MRS at 11.7 T.

Rothe M, Wessel C, Cames S, Szendroedi J, Burkart V, Hwang JH, Roden M. NMR Biomed. 2020 Oct 6:e4422. doi: 10.1002/nbm.4422.

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The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease.

Eslam M, Sarin SK, Wong VW, Fan JG, Kawaguchi T, Ahn SH, Zheng MH, Shiha G, Yilmaz Y, Gani R, Alam S, Dan YY, Kao JH, Hamid S, Cua IH, Chan WK, Payawal D, Tan SS, Tanwandee T, Adams LA, Kumar M, Omata M, George J. Hepatol Int. 2020 Oct 1. doi: 10.1007/s12072-020-10094-2.

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Role of Agents for the Treatment of Diabetes in the Management of Nonalcoholic Fatty Liver Disease.

Budd J, Cusi K. Curr Diab Rep. 2020 Oct 5;20(11):59. doi: 10.1007/s11892-020-01349-1.

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ABIDE: an accurate predictive model of liver decompensation in patients with non-alcoholic fatty liver-related cirrhosis.

Calzadilla-Bertot L, Vilar-Gomez E, Wong VW, Romero-Gomez M, Aller-de la Fuente R, Wong GL, Castellanos M, Eslam M, Desai AP, Jeffrey GP, George J, Chalasani N, Adams LA. Hepatology. 2020 Sep 25. doi: 10.1002/hep.31576.

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Optimal Threshold of Controlled Attenuation Parameter for Detection of HIV-Associated NAFLD With Magnetic Resonance Imaging as the Reference Standard.

Ajmera VH, Cachay ER, Ramers CB, Bassirian S, Singh S, Bettencourt R, Richards L, Hamilton G, Middleton M, Fowler K, Sirlin C, Loomba R. Clin Infect Dis. 2020 Sep 25:ciaa429. doi: 10.1093/cid/ciaa429.

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Association Between Lipoprotein Particles and Atherosclerotic Events in Nonalcoholic Fatty Liver Disease.

Patel S, Siddiqui MB, Roman JH, Zhang E, Lee E, Shen S, Faridnia M, Mintini RJ, Boyett S, Idowu MO, Sanyal AJ, Luketic VA, Siddiqui MS. Clin Gastroenterol Hepatol. 2020 Sep 29:S1542-3565(20)31369-0. doi: 10.1016/j.cgh.2020.09.039.

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The times they are a-changin’ (for NAFLD as well).

Ratziu V, Rinella M, Beuers U, Loomba R, Anstee QM, Harrison S, Francque S, Sanyal A, Newsome PN, Younossi Z. J Hepatol. 2020 Sep 2:S0168-8278(20)33599-6. doi: 10.1016/j.jhep.2020.08.028.

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Dietary Rapeseed Oil Supplementation Reduces Hepatic Steatosis in Obese Men – A Randomized Controlled Trial.

Kruse M, Kemper M, Gancheva S, Osterhoff M, Dannenberger D, Markgraf D, Machann J, Hierholzer J, Roden M, Pfeiffer AFH. Mol Nutr Food Res. 2020 Sep 13:e2000419. doi: 10.1002/mnfr.202000419.

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Clinical endpoints are necessary in the interim analysis of REGENERATE – Authors’ reply.

Ratziu V, Younossi ZM, Campagna JA, MacConell L, Sanyal AJ. Lancet. 2020 Sep 5;396(10252):663-664. doi: 10.1016/S0140-6736(20)30807-2.

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A New, Non-Invasive Scale for Steatosis Developed Using Real-World Data From Russian Outpatients to Aid in the Diagnosis of Non-Alcoholic Fatty Liver Disease.

Maev IV, Samsonov AA, Lazebnik LB, Golovanova EV, Pavlov CS, Vovk EI, Ratziu V, Starostin KM. Adv Ther. 2020 Sep 16. doi: 10.1007/s12325-020-01493-w.

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CPAP Did Not Improve Nonalcoholic Fatty Liver Disease in Patients with Obstructive Sleep Apnea: A Randomized Clinical Trial.

Ng SS, Wong VW, Wong GL, Chu WC, Chan TO, To KW, Ko FW, Chan KP, Hui DS. Am J Respir Crit Care Med. 2020 Sep 14. doi: 10.1164/rccm.202005-1868OC.

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Management of chronic liver disease-associated severe thrombocytopenia in Spain: a view from the experts.

Calleja-Panero JL, Andrade RJ, Bañares R, Crespo J, Esteban R, Jarque I, Mingot-Castellano ME, Romero-Gómez M, Muñoz-Peñín R, Bentley R, Shepherd J, Gil Aguirre A. Rev Esp Enferm Dig. 2020 Sep 21;112. doi: 10.17235/reed.2020.6895/2020.

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Clinical assessment for high-risk patients with non-alcoholic fatty liver disease in primary care and diabetology practices.

Younossi ZM, Corey KE, Alkhouri N, Noureddin M, Jacobson I, Lam B, Clement S, Basu R, Gordon SC, Ravendhra N, Puri P, Rinella M, Scudera P, Singal AK, Henry L; US Members of the Global Nash Council. Aliment Pharmacol Ther. 2020 Aug;52(3):513-526. doi: 10.1111/apt.15830. Epub 2020 Jun 29.PMID: 32598051

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From NAFLD to MAFLD: a “redefining” moment for fatty liver disease.

Zheng KI, Fan JG, Shi JP, Wong VW, Eslam M, George J, Zheng MH. Chin Med J (Engl). 2020 Jul 21. doi: 10.1097/CM9.0000000000000981. Online ahead of print.PMID: 32701591 

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Evidence-based clinical advice for nutrition and dietary weight loss strategies for the management of NAFLD and NASH.

Hydes TJ, Ravi S, Loomba R, E Gray M. Clin Mol Hepatol. 2020 Jul 17. doi: 10.3350/cmh.2020.0067. Online ahead of print.PMID: 32674529 

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Nonalcoholic fatty liver disease and the risk of metabolic comorbidities: how to manage in clinical practice.

Perdomo C, D'Ingianna P, Escalada J, Petta S, Romero Gómez M, Ampuero J. Pol Arch Intern Med. 2020 Jul 14. doi: 10.20452/pamw.15510. Online ahead of print.PMID: 32666779

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Physical Activity, Measured Objectively, is Associated With Lower Mortality in Patients With Nonalcoholic Fatty Liver Disease.

Kim D, Murag S, Cholankeril G, Cheung A, Harrison SA, Younossi ZM, Ahmed A. Clin Gastroenterol Hepatol. 2020 Jul 16:S1542-3565(20)30985-X. doi: 10.1016/j.cgh.2020.07.023. Online ahead of print.PMID: 32683103

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Cilofexor, a Nonsteroidal FXR Agonist, in Patients With Noncirrhotic NASH: A Phase 2 Randomized Controlled Trial.

Patel K, Harrison SA, Elkhashab M, Trotter JF, Herring R, Rojter SE, Kayali Z, Wong VW, Greenbloom S, Jayakumar S, Shiffman ML, Freilich B, Lawitz EJ, Gane EJ, Harting E, Xu J, Billin AN, Chung C, Djedjos CS, Subramanian GM, Myers RP, Middleton MS, Rinella M, Noureddin M. Hepatology. 2020 Jul;72(1):58-71. doi: 10.1002/hep.31205.PMID: 32115759

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MR elastography-based liver fibrosis correlates with liver events in nonalcoholic fatty liver patients: A multicenter study.

Han MAT, Vipani A, Noureddin N, Ramirez K, Gornbein J, Saouaf R, Baniesh N, Cummings-John O, Okubote T, Setiawan VW, Rotman Y, Loomba R, Alkhouri N, Noureddin M. Liver Int. 2020 Jul 11. doi: 10.1111/liv.14593. Online ahead of print.PMID: 32652744

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The PREDICT study uncovers three clinical courses in acutely decompensated cirrhosis with distinct pathophysiology.

Trebicka J, Fernandez J, Papp M, Caraceni P, Laleman W, Gambino C, Giovo I, Uschner FE, Jimenez C, Mookerjee R, Gustot T, Albillos A, Bañares R, Janicko M, Steib C, Reiberger T, Acevedo J, Gatti P, Bernal W, Zeuzem S, Zipprich A, Piano S, Berg T, Bruns T, Bendtsen F, Coenraad M, Merli M, Stauber R, Zoller H, Ramos JP, Solé C, Soriano G, de Gottardi A, Gronbaek H, Saliba F, Trautwein C, Özdogan OC, Francque S, Ryder S, Nahon P, Romero-Gomez M, Van Vlierberghe H, Francoz C, Manns M, Garcia E, Tufoni M, Amoros A, Pavesi M, Sanchez C, Curto A, Pitarch C, Putignano A, Moreno E, Shawcross D, Aguilar F, Claria J, Ponzo P, Jansen C, Vitalis Z, Zaccherini G, Balogh B, Vargas V, Montagnese S, Alessandria C, Bernardi M, Ginès P, Jalan R, Moreau R, Angeli P, Arroyo V; PREDICT STUDY group of the EASL-CLIF CONSORTIUM. J Hepatol. 2020 Jul 13:S0168-8278(20)30384-6. doi: 10.1016/j.jhep.2020.06.013. Online ahead of print.PMID: 32673741 

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Significant fibrosis predicts new-onset diabetes mellitus and arterial hypertension in patients with NASH.

Ampuero J, Aller R, Gallego-Durán R, Crespo J, Calleja JL, García-Monzón C, Gómez-Camarero J, Caballería J, Lo Iacono O, Ibañez L, García-Samaniego J, Albillos A, Francés R, Fernández-Rodríguez C, Diago M, Soriano G, Andrade RJ, Latorre R, Jorquera F, Morillas RM, Escudero D, Estévez P, Hernandez-Guerra M, Augustín S, Bañales J, Aspichueta P, Benlloch S, Rosales JM, Salmerón J, Turnes J, Romero-Gómez M; HEPAmet Registry. J Hepatol. 2020 Jul;73(1):17-25. doi: 10.1016/j.jhep.2020.02.028.

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Intestinal Virome Signature Associated With Severity of Nonalcoholic Fatty Liver Disease.

Lang S, Demir M, Martin A, Jiang L, Zhang X, Duan Y, Gao B, Wisplinghoff H, Kasper P, Roderburg C, Tacke F, Steffen HM, Goeser T, Abraldes JG, Tu XM, Loomba R, Stärkel P, Pride D, Fouts DE, Schnabl B. Gastroenterology. 2020 Jul 8:S0016-5085(20)34923-4. doi: 10.1053/j.gastro.2020.07.005. Online ahead of print.PMID: 32652145

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Review article: The impact of liver-directed therapies on the atherogenic risk profile in non-alcoholic steatohepatitis.

Connelly MA, Velez Rivera J, Guyton JR, Siddiqui MS, Sanyal AJ. Aliment Pharmacol Ther. 2020 Jul 8. doi: 10.1111/apt.15935. Online ahead of print.PMID: 32638417 

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Real-World Burden of Nonalcoholic Steatohepatitis.

Geier A, Rinella M, Balp MM, McKenna SJ, Brass C, Przybysz R, Cai J, Knight A, Gavaghan M, Howe T, Rosen D, Ratziu V. Clin Gastroenterol Hepatol. 2020 Jul 4:S1542-3565(20)30928-9. doi: 10.1016/j.cgh.2020.06.064. Online ahead of print.PMID: 32634622

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Patient-reported outcomes in patients with non-alcoholic fatty liver disease: A narrative review of Chronic Liver Disease Questionnaire-non-alcoholic fatty liver disease/non-alcoholic steatohepatitis.

Yamamura S, Nakano D, Hashida R, Tsutsumi T, Kawaguchi T, Okada M, Isoda H, Takahashi H, Matsuse H, Eguchi Y, Sumida Y, Nakajima A, Gerber L, Younossi ZM, Torimura T. J Gastroenterol Hepatol. 2020 Jul 6. doi: 10.1111/jgh.15172. Online ahead of print.PMID: 32627871 

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Monitoring Occurrence of Liver-Related Events and Survival by Transient Elastography in Patients With Nonalcoholic Fatty Liver Disease and Compensated Advanced Chronic Liver disease.

Petta S, Sebastiani G, Viganò M, Ampuero J, Wai-Sun Wong V, Boursier J, Berzigotti A, Bugianesi E, Fracanzani AL, Cammà C, Enea M, Grottes MD, Di Marco V, Younes R, Keyrouz A, Mazzola S, Mendoza Y, Pennisi G, Romero-Gomez M, Craxì A, de Ledinghen V. Clin Gastroenterol Hepatol. 2020 Jul 1:S1542-3565(20)30908-3. doi: 10.1016/j.cgh.2020.06.045. Online ahead of print.PMID: 32621970

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Important Unresolved Questions in the Management of Hepatic Encephalopathy: An ISHEN Consensus.

Bajaj JS, Lauridsen M, Tapper EB, Duarte-Rojo A, Rahimi RS, Tandon P, Shawcross DL, Thabut D, Dhiman RK, Romero-Gomez M, Sharma BC, Montagnese S. Am J Gastroenterol. 2020 Jul;115(7):989-1002. doi: 10.14309/ajg.0000000000000603.PMID: 32618647

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What Has the COVID-19 Pandemic Taught Us so Far? Addressing the Problem from a Hepatologist’s Perspective.

Méndez-Sánchez N, Valencia-Rodríguez A, Qi X, Yoshida EM, Romero-Gómez M, George J, Eslam M, Abenavoli L, Xie W, Teschke R, Carrion AF, Keaveny AP.
J Clin Transl Hepatol. 2020 Jun 28;8(2):0024. doi: 10.14218/JCTH.2020.00024. Epub 2020 Apr 11.

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Mitochondrial oxidative injury: A key player in nonalcoholic fatty liver disease.

Dornas W, Schuppan D. Am J Physiol Gastrointest Liver Physiol. 2020 Jun 29. doi: 10.1152/ajpgi.00121.2020. Online ahead of print.PMID: 32597705

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A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis.

Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Raffatellu M, Dorrestein PC, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin CB, Knight R, Downes M, Evans RM, Loomba R. Cell Metab. 2020 Jun 30:S1550-4131(20)30306-5. doi: 10.1016/j.cmet.2020.06.005. Online ahead of print.PMID: 32610095

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Metabolic liver disease in diabetes – From mechanisms to clinical trials.

Dewidar B, Kahl S, Pafili K, Roden M. Metabolism. 2020 Jun 20:154299. doi: 10.1016/j.metabol.2020.154299. Online ahead of print.PMID: 32569680 

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Novel antisense inhibition of diacylglycerol O-acyltransferase 2 for treatment of non-alcoholic fatty liver disease: a multicentre, double-blind, randomised, placebo-controlled phase 2 trial.

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Zhao P, Sun X, Chaggan C, Liao Z, In Wong K, He F, Singh S, Loomba R, Karin M, Witztum JL, Saltiel AR.
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Paik JM, Golabi P, Younossi Y, Mishra A, Younossi ZM.
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MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease.

Eslam M, Sanyal AJ, George J; an international consensus panel.
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Taylor RS, Taylor RJ, Bayliss S, Hagstrom H, Nasr P, Schattenberg JM, Ishigami M, Toyoda H, Wai-Sun Wong V, Peleg N, Shlomai A, Sebastiani G, Seko Y, Bhala N, Younossi ZM, Anstee QM, McPherson S, Newsome PN; Collaborators.
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Assessment of Hepatic Steatosis in Nonalcoholic Fatty Liver Disease by Using Quantitative US.

Han A, Zhang YN, Boehringer AS, Montes V, Andre MP, Erdman JW Jr, Loomba R, Valasek MA, Sirlin CB, O'Brien WD Jr.
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Gore E, Bigaeva E, Oldenburger A, Jansen YJM, Schuppan D, Boersema M, Rippmann JF, Broermann A, Olinga P.
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Non-Alcoholic Fatty Liver Disease: What Does the Primary Care Physician Need to Know?

Budd J, Cusi K.
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The role of nutrition in non-alcoholic fatty liver disease: Pathophysiology and management.

Berná G, Romero-Gomez M.
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Current management of non-alcoholic steatohepatitis.

Muthiah MD, Sanyal AJ.
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New drugs for non-alcoholic steatohepatitis.

Cardoso AC, de Figueiredo-Mendes C, A Villela-Nogueira C, Sanyal AJ.

Liver Int. 2020 Feb;40 Suppl 1:96-101. doi: 10.1111/liv.14354.

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Time to Include Nonalcoholic Steatohepatitis in the Management of Patients With Type 2 Diabetes.

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Diabetes Care. 2020 Feb;43(2):275-279. doi: 10.2337/dci19-0064.

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Role of Exercise in Mitigating Pediatric Nonalcoholic Fatty Liver Disease.

Vittorio JM, Lavine JE.
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β-arrestin: Dr Jekyll and Mr Hyde in NASH and fibrosis.

Abe H, Schuppan D.
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Fatty liver disease: putting the spotlight on a silent menace for young adults.

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Lancet Gastroenterol Hepatol. 2020 Mar;5(3):236-238. doi: 10.1016/S2468-1253(19)30420-0. Epub 2020 Jan 15. No abstract available.
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Loomba R, Neuschwander-Tetri BA, Sanyal A, Chalasani N, Diehl AM, Terrault N, Kowdley K, Dasarathy S, Kleiner D, Behling C, Lavine J, Van Natta M, Middleton M, Tonascia J, Sirlin C; NASH Clinical Research Network.
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AGA Clinical Practice Update on Screening and Surveillance for Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease: Expert Review.

Loomba R, Lim JK, Patton H, El-Serag HB.
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Collagen biology and non-invasive biomarkers of liver fibrosis.

Karsdal MA, Daniels SJ, Holm Nielsen S, Bager C, Rasmussen DGK, Loomba R, Surabattula R, Villesen IF, Luo Y, Shevell D, Gudmann NS, Nielsen MJ, George J, Christian R, Leeming DJ, Schuppan D.
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Cenicriviroc Treatment for Adults with Nonalcoholic Steatohepatitis and Fibrosis: Final Analysis of the Phase 2b CENTAUR Study.

Ratziu V, Sanyal A, Harrison SA, Wong VW, Francque S, Goodman Z, Aithal GP, Kowdley KV, Seyedkazemi S, Fischer L, Loomba R, Abdelmalek MF, Tacke F.
Hepatology. 2020 Jan 13. doi: 10.1002/hep.31108.

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Low Awareness of Nonalcoholic Fatty Liver Disease in a Population-Based Cohort Sample: the CARDIA Study.

Cleveland ER, Ning H, Vos MB, Lewis CE, Rinella ME, Carr JJ, Lloyd-Jones DM, VanWagner LB.
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Factors to Consider in Development of Drugs for Pediatric Nonalcoholic Fatty Liver Disease.

Vos MB, Dimick-Santos L, Mehta R, Omokaro SO, Taminiau J, Schabel E, Kleiner DE, Szitanyi P, Socha P, Schwimmer JB, Noviello S, Silberg DG, Torstenson R, Miller V, Lavine JE; Liver Forum Pediatric Working Group.
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Crosstalk between adipose tissue insulin resistance and liver macrophages in non-alcoholic fatty liver disease.

Rosso C, Kazankov K, Younes R, Esmaili S, Marietti M, Sacco M, Carli F, Gaggini M, Salomone F, Møller HJ, Abate ML, Vilstrup H, Gastaldelli A, George J, Grønbæk H, Bugianesi E.
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The impact of modifiable risk factors on the long-term outcomes of non-alcoholic fatty liver disease.

Paik JM, Deshpande R, Golabi P, Younossi I, Henry L, Younossi ZM.
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The Role of Noninvasive Tests for Differentiating NASH From NAFL and Diagnosing Advanced Fibrosis Among Patients With NAFLD.

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J Clin Gastroenterol. 2019 Nov 26. doi: 10.1097/MCG.0000000000001284.

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Performance of liver biomarkers, in patients at risk of nonalcoholic steato-hepatitis, according to presence of type-2 diabetes.

Poynard T, Peta V, Deckmyn O, Pais R, Ngo Y, Charlotte F, Ngo A, Munteanu M, Imbert-Bismut F, Monneret D, Housset C, Thabut D, Valla D, Boitard C, Castera L, Ratziu V; FLIP consortium, the FibroFrance Group, the EPIC-3 program and the QUID-NASH group.
Eur J Gastroenterol Hepatol. 2019 Nov 25. doi: 10.1097/MEG.0000000000001606.

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Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease.

Majdi A, Aoudjehane L, Ratziu V, Islam T, Afonso MB, Conti F, Mestiri T, Lagouge M, Foufelle F, Ballenghien F, Ledent T, Moldes M, Cadoret A, Fouassier L, Delaunay JL, Aït-Slimane T, Courtois G, Fève B, Scatton O, Prip-Buus C, Rodrigues CMP, Housset C, Gautheron J.
J Hepatol. 2019 Nov 21. pii: S0168-8278(19)30678-6. doi: 10.1016/j.jhep.2019.11.008.

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Dietary wheat amylase trypsin inhibitors promote features of murine non-alcoholic fatty liver disease.

Ashfaq-Khan M, Aslam M, Qureshi MA, Senkowski MS, Yen-Weng S, Strand S, Kim YO, Pickert G, Schattenberg JM, Schuppan D.
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A randomized, double-blind, multicenter, phase 2b study to evaluate the safety and efficacy of a combination of tropifexor and cenicriviroc in patients with nonalcoholic steatohepatitis and liver fibrosis: Study design of the TANDEM trial.

Pedrosa M, Seyedkazemi S, Francque S, Sanyal ARinella M, Charlton M, Loomba RRatziu V, Kochuparampil J, Fischer L, Vaidyanathan S, Anstee QM.
Contemp Clin Trials. 2019 Nov 13;88:105889. doi: 10.1016/j.cct.2019.105889.  

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Hypothetical treatment of patients with non-alcoholic steatohepatitis: Potential impact on important clinical outcomes.

Younossi ZM, Tampi RP, Nader F, Younossi IM, Cable R, Srishord M, Racila A.
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Hepatocellular carcinoma and non-alcoholic fatty liver disease.

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Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase IIb study.

Harrison SA, Alkhouri N, Davison BA, Sanyal A, Edwards C, Colca JR, Lee BH, Loomba R, Cusi K, Kolterman O, Cotter G, Dittrich HC.
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Performance of Plasma Biomarkers and Diagnostic Panels for Nonalcoholic Steatohepatitis and Advanced Fibrosis in Patients With Type 2 Diabetes.

Bril F, McPhaul MJ, Caulfield MP, Clark VC, Soldevilla-Pico C, Firpi-Morell RJ, Lai J, Shiffman D, Rowland CM, Cusi K.
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Change in hepatic fat content measured by MRI does not predict treatment-induced histological improvement of steatohepatitis.

Bril F, Barb D, Lomonaco R, Lai J, Cusi K.
J Hepatol. 2019 Oct 4. pii: S0168-8278(19)30584-7. doi: 10.1016/j.jhep.2019.09.018

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Toward More Accurate Nomenclature for Fatty Liver Diseases

Eslam M, Sanyal AJ, George J.
Gastroenterology. 2019 Sep;157(3):590-593. doi: 10.1053/j.gastro.2019.05.064.

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Editorial: It is not a wide-open field for incretins – collateral benefits favour the use of metformin in advanced non-alcoholic steatohepatitis

Ratziu V, Pais R.
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Gene Expression and DNA Methylation Alterations in the Glycine N-Methyltransferase Gene in Diet-Induced Nonalcoholic Fatty Liver Disease-Associated Carcinogenesis

Borowa-Mazgaj B, de Conti A, Tryndyak V, Steward CR, Jimenez L, Melnyk S, Seneshaw M, Mirshahi F, Rusyn I, Beland FA, Sanyal AJ, Pogribny IP.
Toxicol Sci. 2019 Aug 1;170(2):273-282. doi: 10.1093/toxsci/kfz110.

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Non-alcoholic fatty liver disease in Asia: How is it different from the West?

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J Gastroenterol Hepatol. 2019 Aug;34(8):1267-1268. doi: 10.1111/jgh.14813.

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Role of Vitamin E for Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes: A Randomized Controlled Trial

Bril F, Biernacki DM, Kalavalapalli S, Lomonaco R, Subbarayan SK, Lai J, Tio F, Suman A, Orsak BK, Hecht J, Cusi K.
Diabetes Care. 2019 Aug;42(8):1481-1488. doi: 10.2337/dc19-0167.

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Degradation of splicing factor SRSF3 contributes to progressive liver disease

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Nobili V, Mantovani A, Cianfarani S, Alisi A, Mosca A, Sartorelli MR, Maffeis C, Loomba R, Byrne CD, Targher G.
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Neurocognitive Deficits in a Cohort With Class 2 and Class 3 Obesity: Contributions of Type 2 Diabetes and Other Comorbidities

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REGENERATE: Design of a pivotal, randomised, phase 3 study evaluating the safety and efficacy of obeticholic acid in patients with fibrosis due to nonalcoholic steatohepatitis

Ratziu V, Sanyal AJ, Loomba R, Rinella M, Harrison S, Anstee QM, Goodman Z, Bedossa P, MacConell L, Shringarpure R, Shah A, Younossi Z.
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Development and Validation of Hepamet Fibrosis Scoring System A Simple, Noninvasive Test to Identify Patients With Nonalcoholic Fatty Liver Disease With Advanced Fibrosis

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Are Non-alcoholic Fatty Liver Disease and Alcoholic Fatty Liver Disease More Than Just Semantics?

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Bashir M, Wolfson T4, Gamst AC, Fowler KJ, Ohliger M, Shah SN, Alazraki A, Trout AT, Behling C, Allende DS, Loomba R, Sanyal A, Schwimmer J, Lavine JE, Shen W, Tonascia J, Van Natta ML, Mamidipalli A, Hooker J, Kowdley KV, Middleton MS, Sirlin CB; NASH Clinical Research Network (NASH CRN).
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Defining Improvement in Nonalcoholic Steatohepatitis for Treatment Trial Endpoints: Recommendations from the Liver Forum.

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Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.

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Gallego-Durán R, Álvarez-Amor L, Gil-Gómez A, Rojas Á, Muñoz-Hernández R, Cádernas-García A, Maya-Miles D, Montero-Vallejo R, Gato S, Sánchez Torrijos Y, Ampuero J, Martín F, Romero-Gómez M.
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Higher levels of serum uric acid influences hepatic damage in patients with non-alcoholic fatty liver disease (NAFLD).

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Consensus: guidelines: best practices for detection, assessment and management of suspected acute drug-induced liver injury during clinical trials in patients with nonalcoholic steatohepatitis.

Regev A, Palmer M, Avigan MI, Dimick-Santos L, Treem WR, Marcinak JF, Seekins D, Krishna G, Anania FA, Freston JW, Lewis JH, Sanyal AJ, Chalasani N.
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Plasma Fibroblast Growth Factor 21 is Associated with Severity of Nonalcoholic Steatohepatitis in Patients with Obesity and Type 2 Diabetes.

Barb D, Bril F, Kalavalapalli S, Cusi K.
J Clin Endocrinol Metab. 2019 Mar 8. pii: jc.2018-02414. doi: 10.1210/jc.2018-02414.

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The diagnostic performance of a simplified blood test (SteatoTest-2) for the prediction of liver steatosis.

Poynard T, Peta V, Munteanu M, Charlotte F, Ngo Y, Ngo A, Perazzo H, Deckmyn O, Pais R, Mathurin P, Myers R, Loomba R, Ratziu V; FLIP consortium, the FibroFrance-CPAM group, the FibroFrance-Obese group, and the Selonsertib group.
Eur J Gastroenterol Hepatol. 2019 Mar;31(3):393-402. doi: 10.1097/MEG.0000000000001304.

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The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

Kazankov K, Jørgensen SMD, Thomsen KL, Møller HJ, Vilstrup H, George J, Schuppan D, Grønbæk H.
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Reduced Patient-Reported Outcome Scores Associate with Level of Fibrosis in Patients with Nonalcoholic Steatohepatitis.

Younossi ZM, Stepanova M, Anstee QM, Lawitz EJ, Wai-Sun Wong V, Romero-Gomez M, Kersey K, Li G, Subramanian GM, Myers RP, Djedjos CS, Okanoue T, Trauner M, Goodman Z, Harrison SA.
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Non-Invasive Assessment of Liver Disease in Patients with NAFLD.

Castera L, Friedrich-Rust M, Loomba R.
Gastroenterology. 2019 Jan 17. pii: S0016-5085(19)30051-4. doi: 10.1053/j.gastro.2018.12.036.

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Banini B, Cazanave SC, Yates KP, Asgharpour A, Vincent R, Mirshahi F, Le P, Contos MJ, Tonascia J, Chalasani NP, Kowdley KV, McCullough AJ, Behling CA, Schwimmer JB, Lavine JE, Sanyal AJ; Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN).
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